Potential role of angiotensin receptor antagonists in renal protection

K. Hayashi, H. Matsuda, M. Honda, T. Saruta

Research output: Contribution to journalReview articlepeer-review


Recent clinical studies have established an important role of angiotensin converting enzyme inhibitors (ACE-I) as a tool for renal protection. Although angiotensin receptor antagonists (AII-A) share the common property with ACE-I with regard to blockade of angiotensin activity via angiotensin type 1 receptors (AT1), AII-A is also reported to stimulate AT2 that plausibly activates nitric oxide production within renal medulla and augments synthesis of vasodilatory P450-metabolites in renal afferent arterioles. In contrast, AII-A is reported to have no effect on bradykinin activity. Results obtained in experimental animals indicate that AII-A effectively prevents the progression of renal injury. Several clinical studies are in progress, and the preliminary results suggest that AII-A has potent renal protective action in a variety of renal disorders.

Original languageEnglish
Pages (from-to)1164-1167
Number of pages4
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number5
Publication statusPublished - 1999 May

ASJC Scopus subject areas

  • Medicine(all)


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