Abstract
Recent clinical studies have established an important role of angiotensin converting enzyme inhibitors (ACE-I) as a tool for renal protection. Although angiotensin receptor antagonists (AII-A) share the common property with ACE-I with regard to blockade of angiotensin activity via angiotensin type 1 receptors (AT1), AII-A is also reported to stimulate AT2 that plausibly activates nitric oxide production within renal medulla and augments synthesis of vasodilatory P450-metabolites in renal afferent arterioles. In contrast, AII-A is reported to have no effect on bradykinin activity. Results obtained in experimental animals indicate that AII-A effectively prevents the progression of renal injury. Several clinical studies are in progress, and the preliminary results suggest that AII-A has potent renal protective action in a variety of renal disorders.
| Original language | English |
|---|---|
| Pages (from-to) | 1164-1167 |
| Number of pages | 4 |
| Journal | Nippon rinsho. Japanese journal of clinical medicine |
| Volume | 57 |
| Issue number | 5 |
| Publication status | Published - 1999 May |
ASJC Scopus subject areas
- General Medicine