Potential role of oxidative stress in ocular surface inflammation and dry eye disease

Murat Dogru, Takashi Kojima, Cem Simsek, Kazuo Tsubotav

Research output: Contribution to journalArticlepeer-review

135 Citations (Scopus)


Reactive oxygen species (ROS) are produced as a by-product during the mitochondrial respiration of the oxygen and potentially able to damage the tissues. Oxidative stress occurs as a result of the disruption of the balance between the anti-oxidant system and the pro-oxidant system found in cells. It has been accepted that overexpression of ROS can be induced in the ocular surface as a result of many acute and chronic diseases and even in normal aging. Recent studies demonstrated that oxidative stress damages the ocular surface and plays an important role in the mechanism of dry eye disease. There is a need to investigate the therapeutic modalities employing topical/systemic use of antioxidants in dry eye disease. This review will summarize the recent studies showing the important relationship between oxidative stress and dry eye disease.

Original languageEnglish
Pages (from-to)DES163-DES168
JournalInvestigative Ophthalmology and Visual Science
Issue number14 Special Issue
Publication statusPublished - 2018 Nov


  • Dry eye
  • Oxidative stress
  • Reactive oxygen species

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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