PPARs and hypertension

Hiroshi Itoh

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


PPARs (peroxisome proliferator-activated receptors) alpha, delta and gamma are expressed in adipocytes, skeletal myocytes and hepatocytes and also in endothelial cells, vascular smooth muscle cells and monocytes/macrophages, in distinct distributions. They are critically involved in the pathophysiology of obesity, diabetes, hyperlipidemia and hypertension, the complex of which is recognized as "metabolic syndrome", as well as, of their vascular complications. In addition to modulation of insulin sensitivity, PPARs can regulate oxidative stress and local production of various vasoactive substances in blood vessels, and thus control vascular tone and remodeling as one of the determinants of hypertension.

Original languageEnglish
Pages (from-to)631-642
Number of pages12
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number4
Publication statusPublished - 2005 Apr
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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