Practical deracemization of NM-3, a synthetic angiogenesis inhibitor

Naoki Kanoh, Ayumi Tomatsu, Tomoyuki Nishikawa, Mitsuaki Ide, Toshio Tsuchida, Kunio Isshiki, Masaya Nakata

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


The practical deracemization of the angiogenesis inhibitor NM-3 is described. The transformation features the diastereoselective addition of optically active pantolactone to a ketene intermediate and hydrolysis of the pantolactone ester.

Original languageEnglish
Pages (from-to)1251-1253
Number of pages3
JournalTetrahedron Asymmetry
Issue number10
Publication statusPublished - 2003 May 16
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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