Practical deracemization of NM-3, a synthetic angiogenesis inhibitor

Naoki Kanoh; Ayumi Tomatsu; Tomoyuki Nishikawa; Mitsuaki Ide; Toshio Tsuchida; Kunio Isshiki; Masaya Nakata

doi:10.1016/S0957-4166(03)00240-4

Practical deracemization of NM-3, a synthetic angiogenesis inhibitor

Naoki Kanoh, Ayumi Tomatsu, Tomoyuki Nishikawa, Mitsuaki Ide, Toshio Tsuchida, Kunio Isshiki, Masaya Nakata

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The practical deracemization of the angiogenesis inhibitor NM-3 is described. The transformation features the diastereoselective addition of optically active pantolactone to a ketene intermediate and hydrolysis of the pantolactone ester.

Original language	English
Pages (from-to)	1251-1253
Number of pages	3
Journal	Tetrahedron Asymmetry
Volume	14
Issue number	10
DOIs	https://doi.org/10.1016/S0957-4166(03)00240-4
Publication status	Published - 2003 May 16
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.1016/S0957-4166(03)00240-4

Cite this

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title = "Practical deracemization of NM-3, a synthetic angiogenesis inhibitor",

abstract = "The practical deracemization of the angiogenesis inhibitor NM-3 is described. The transformation features the diastereoselective addition of optically active pantolactone to a ketene intermediate and hydrolysis of the pantolactone ester.",

author = "Naoki Kanoh and Ayumi Tomatsu and Tomoyuki Nishikawa and Mitsuaki Ide and Toshio Tsuchida and Kunio Isshiki and Masaya Nakata",

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AU - Kanoh, Naoki

AU - Tomatsu, Ayumi

AU - Nishikawa, Tomoyuki

AU - Ide, Mitsuaki

AU - Tsuchida, Toshio

AU - Isshiki, Kunio

AU - Nakata, Masaya

PY - 2003/5/16

Y1 - 2003/5/16

N2 - The practical deracemization of the angiogenesis inhibitor NM-3 is described. The transformation features the diastereoselective addition of optically active pantolactone to a ketene intermediate and hydrolysis of the pantolactone ester.

AB - The practical deracemization of the angiogenesis inhibitor NM-3 is described. The transformation features the diastereoselective addition of optically active pantolactone to a ketene intermediate and hydrolysis of the pantolactone ester.

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M3 - Article

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JO - Tetrahedron Asymmetry

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Practical deracemization of NM-3, a synthetic angiogenesis inhibitor

Abstract

ASJC Scopus subject areas

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