Predictive factors of response to leukocytapheresis therapy for ulcerative colitis

Tomoharu Yajima; Hiromasa Takaishi; Takanori Kanai; Yasushi Iwao; Mamoru Watanabe; Hiromasa Ishii; Toshifumi Hibi

doi:10.1111/j.1744-9987.1998.tb00087.x

Predictive factors of response to leukocytapheresis therapy for ulcerative colitis

Tomoharu Yajima, Hiromasa Takaishi, Takanori Kanai, Yasushi Iwao, Mamoru Watanabe, Hiromasa Ishii, Toshifumi Hibi

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Leukocytapheresis (LCAP) using a leukocyte removal filter was performed for 8 patients with moderate to severe ulcerative colitis (UC). Significant clinical improvement was attained in 5 of 8 patients (62.5%). All of them had been suffering from moderately active colitis and received corticosteroid therapy. On the other hand, 3 patients with severely active disease and treated with little or no corticosteroid were resistant to LCAP. This result indicates that LCAP is an effective treatment for steroid-resistant cases of UC when combined with steroid therapy. LCAP alone, however, seems to have little efficacy for severely active UC.

Original language	English
Pages (from-to)	115-119
Number of pages	5
Journal	Therapeutic Apheresis
Volume	2
Issue number	2
DOIs	https://doi.org/10.1111/j.1744-9987.1998.tb00087.x
Publication status	Published - 1998 May

Keywords

Leukocytapheresis
Steroid resistant therapy
Ulcerative colitis

ASJC Scopus subject areas

Medicine(all)

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10.1111/j.1744-9987.1998.tb00087.x

Cite this

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title = "Predictive factors of response to leukocytapheresis therapy for ulcerative colitis",

abstract = "Leukocytapheresis (LCAP) using a leukocyte removal filter was performed for 8 patients with moderate to severe ulcerative colitis (UC). Significant clinical improvement was attained in 5 of 8 patients (62.5%). All of them had been suffering from moderately active colitis and received corticosteroid therapy. On the other hand, 3 patients with severely active disease and treated with little or no corticosteroid were resistant to LCAP. This result indicates that LCAP is an effective treatment for steroid-resistant cases of UC when combined with steroid therapy. LCAP alone, however, seems to have little efficacy for severely active UC.",

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AU - Yajima, Tomoharu

AU - Takaishi, Hiromasa

AU - Kanai, Takanori

AU - Iwao, Yasushi

AU - Watanabe, Mamoru

AU - Ishii, Hiromasa

AU - Hibi, Toshifumi

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N2 - Leukocytapheresis (LCAP) using a leukocyte removal filter was performed for 8 patients with moderate to severe ulcerative colitis (UC). Significant clinical improvement was attained in 5 of 8 patients (62.5%). All of them had been suffering from moderately active colitis and received corticosteroid therapy. On the other hand, 3 patients with severely active disease and treated with little or no corticosteroid were resistant to LCAP. This result indicates that LCAP is an effective treatment for steroid-resistant cases of UC when combined with steroid therapy. LCAP alone, however, seems to have little efficacy for severely active UC.

AB - Leukocytapheresis (LCAP) using a leukocyte removal filter was performed for 8 patients with moderate to severe ulcerative colitis (UC). Significant clinical improvement was attained in 5 of 8 patients (62.5%). All of them had been suffering from moderately active colitis and received corticosteroid therapy. On the other hand, 3 patients with severely active disease and treated with little or no corticosteroid were resistant to LCAP. This result indicates that LCAP is an effective treatment for steroid-resistant cases of UC when combined with steroid therapy. LCAP alone, however, seems to have little efficacy for severely active UC.

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Predictive factors of response to leukocytapheresis therapy for ulcerative colitis

Abstract

Keywords

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