Predictors of New-Onset Atrial Tachyarrhythmias After Transcatheter Atrial Septal Defect Closure in Adults

Kotaro Miura, Mai Kimura, Atsushi Anzai, Takahide Arai, Takashi Kawakami, Shinsuke Yuasa, Kentaro Hayashida, Jin Endo, Hikaru Tsuruta, Yuji Itabashi, Akio Kawamura, Keiichi Fukuda, Hideaki Kanazawa

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Background: New-onset atrial tachyarrhythmia (ATA) often develops after atrial septal defect (ASD) closure. Its development raises some potential concerns such as stroke and bleeding complications caused by anticoagulant therapy and limited access to the left atrium for catheter ablation. Although it is essential to identify the risk factors of new-onset ATA, few studies have examined these factors. This study investigated unknown risk factors for the development of new-onset ATA after transcatheter ASD closure in patients without a history of ATA. Methods: A total of 238 patients without a history of ATA, aged ≥18 years and who underwent transcatheter ASD closure at the current hospital were reviewed. Patient characteristics were compared between the groups with and without new-onset ATA. The factors associated with new-onset ATA were examined using univariate and multivariable analyses. Results: Thirteen (13) (5.5%) patients experienced ATA during follow-up (mean, 21±14 months). Compared with patients without new-onset ATA, patients with new-onset ATA were older (48±18 vs 66±11 years; p<0.001) and had high brain natriuretic peptide (BNP) levels (36±36 vs 177±306 pg/mL; p<0.001). On multivariable analysis, BNP ≥40 pg/mL before ASD closure was associated with new-onset ATA after adjusting for age (OR, 4.91; 95% CI, 1.22–19.8; p=0.025). Conclusion: Patients with BNP levels >40 pg/mL before transcatheter ASD closure may have a higher risk of developing new-onset ATA.

Original languageEnglish
Pages (from-to)1406-1413
Number of pages8
JournalHeart Lung and Circulation
Issue number9
Publication statusPublished - 2021 Sept


  • Atrial septal defect
  • Atrial tachyarrhythmia
  • Brain natriuretic peptide
  • Percutaneous atrial septal defect closure

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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