Pregnancy and delivery in patients with repaired congenital heart disease - A retrospective japanese multicenter study - A r

Shinichi Takatsuki, Yoshiyuki, Phd Furutani, Kei Inai, Tohru Kobayashi, Ryo Inuzuka, Tomomi Uyeda, Mitsuhiro Kamisago, Jun Muneuchi, Masahide Kaneko, Yasushi Misaki, Hiroshi Ono, Hitoshi Kato, Eriko Shimada, Tokuko Shinohara, Kenji Waki, Kenji Suda, Yasunobu Hayabuchi, Hirotaka Ohki, Reina Ishizaki, Jun MaedaHiroyuki Yamagishi

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Background: Although advances in cardiac surgery have led to an increased number of survivors with congenital heart disease (CHD), epidemiological data regarding the pregnancies and deliveries of patients with repaired CHD are scarce. Methods and Results: In this study, we retrospectively reviewed the clinical outcomes of pregnancies and deliveries of women with repaired CHD. Overall, 131 women with repaired CHD were enrolled and there were 269 gestations. All patients were classified as New York Heart Association (NYHA) Class I or II. The prevalence of cesarean sections was higher in patients with (CyCHD) than without (AcyCHD) a past history of cyanosis (51% vs. 19%, respectively; P<0.01). There were 228 offspring from 269 gestations and the most prevalent neonatal complication was premature birth (10%), which was more frequent in the CyCHD than AcyCHD group (15.7% vs. 5.6%, respectively; P<0.01). Five maternal cardiac complications during delivery were observed only in the CyCHD group (8%); these were classified as NYHA Class II and none was fatal. Conclusions: Delivery was successful in most women with repaired CHD who were classified as NYHA Class I or II, although some with CyCHD and NYHA Class II required more attention. Cesarean sections were more common in the CyCHD than AcyCHD group, and CyCHD may be a potential risk for preterm deliveries.

Original languageEnglish
Pages (from-to)2270-2274
Number of pages5
JournalCirculation Journal
Issue number12
Publication statusPublished - 2020


  • Adult congenital heart disease
  • Cesarean section
  • Premature
  • Tetralogy of Fallot

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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