Preparation and properties of thermosensitive hydrogel microcapsules

Kimiko Makino, Yohei Fujita, Ken ichi Takao, Susumu Kobayashi, Hiroyuki Ohshima

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Temperature-sensitive hydrophilic gel microcapsules have been newly prepared. That is, poly (L-lysineisopropylamide-terephthalic acid) microcapsules containing water have been obtained by an interfacial polymerization at a water/oil interface between L-lysineisopropylamide and terephthaloyldichloride. The microcapsule changes its size between 33 and 35°C. Under 33°C, the microcapsules are fully spherical and can be redispersed in distilled water, while are aggregated above 35°C. The microcapsules, which are observed to show aggregation above 33°C, can be redispersed by decreasing temperature within a few second. The thermosensitive morphological changes of the microcapsules are thus reversible. Also, it has been shown that the permeability of sodium chloride through the microcapsule membrane changes remarkably between 33 and 35°C, while it is kept almost constant independent of temperature between 25 and 33°C or between 35 and 55°C. The permeability of solutes is higher under 33°C than that above 35°C. Such thermosensitive properties result from the fact that the polymer membrane has isopropylamide groups. That is, L-lysineisopropylamide has a chemical structure similar to N-isopropylacrylamide, the polymer of which, poly (N-isopropylacrylamide), is a thermosensitive hydrogel having its phase transition temperature around 33°C.

Original languageEnglish
Pages (from-to)259-263
Number of pages5
JournalColloids and Surfaces B: Biointerfaces
Issue number4
Publication statusPublished - 2001
Externally publishedYes


  • Hydrophilic gel
  • L-Lysineisopropylamide
  • Microcapsule
  • Poly (N-isopropylacrylamide)
  • Temperature-sensitive
  • Thermosensitive

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry


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