Abstract
A tetrapeptide RGDS (Arg-Gly-Asp-Ser), which is one of the active sites of cell adhesive proteins, was synthesized according to the solution method and covalently coupled onto monodisperse microspheres. The biospecific activity of the RGDS-carrying microspheres was investigated by measuring the stimulatory effect of the microspheres on platelets. Large and tightly packed platelet aggregation accompanied with drastic ATP release was induced by the RGDS-carrying microspheres. It was confirmed that the specific platelet aggregation was attributed to the activity of the immobilized RGDS by comparison with those induced by other microspheres.
| Original language | English |
|---|---|
| Pages (from-to) | 369-380 |
| Number of pages | 12 |
| Journal | Journal of Biomaterials Science, Polymer Edition |
| Volume | 4 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1993 |
Keywords
- Microsphere
- RGDS
- biospecific activity
- cell adhesion
- platelet aggregation
ASJC Scopus subject areas
- Biophysics
- Bioengineering
- Biomaterials
- Biomedical Engineering
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