Pretreatment Hematologic Findings as Novel Predictive Markers for Facial Palsy Prognosis

Koichiro Wasano, Taiji Kawasaki, Sayuri Yamamoto, Shuta Tomisato, Seiichi Shinden, Toru Ishikawa, Shujiro Minami, Takeshi Wakabayashi, Kaoru Ogawa

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Objective To examine the relationship between prognosis of 2 different facial palsies and pretreatment hematologic laboratory values. Study Design Multicenter case series with chart review. Setting Three tertiary care hospitals. Subjects and Methods We examined the clinical records of 468 facial palsy patients who were treated with an antiviral drug in combination with either oral or intravenous corticosteroids in participating hospitals between 2010 and 2014. Patients were divided into a Bell's palsy group or a Hunt's palsy group. We used the Yanagihara facial nerve grading system to grade the severity of facial palsy. "Recovery" from facial palsy was defined as achieving a Yanagihara score ≥36 points within 6 months of onset and having no accompanying facial contracture or synkinesis. We collected information about pretreatment hematologic findings, demographic data, and electrophysiologic test results of the Bell and Hunt group patients who recovered and those who did not. We then compared these data across the 2 palsy groups. Results In the Bell's palsy group, recovered and unrecovered patients differed significantly in age, sex, electroneuronography score, stapedial muscle reflex, neutrophil rate, lymphocyte rate, neutrophil-to-lymphocyte ratio, and initial Yanagihara score. In the Hunt's palsy group, recovered and unrecovered patients differed in age, electroneuronography score, stapedial muscle reflex, monocyte rate, platelet count, mean corpuscular volume, and initial Yanagihara score. Conclusions Pretreatment hematologic findings, which reflect the severity of inflammation and bone marrow dysfunction caused by a virus infection, are useful for predicting the prognosis of facial palsy.

Original languageEnglish
Pages (from-to)581-587
Number of pages7
JournalOtolaryngology - Head and Neck Surgery (United States)
Issue number4
Publication statusPublished - 2016 Oct 1


  • Bell's palsy
  • Yanagihara score
  • biomarker
  • bone marrow dysfunction
  • facial palsy
  • prognosis
  • severity of virus infection

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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