Prevalence of interrelated autoantibodies in thyroid diseases and autoimmune disorders

Hideki Nakamura, T. Usa, M. Motomura, T. Ichikawa, K. Nakao, E. Kawasaki, M. Tanaka, K. Ishikawa, K. Eguchi

Research output: Contribution to journalArticlepeer-review

77 Citations (Scopus)


Objective: We determined the autoantibody profile in autoimmune thyroid diseases (AITD) and examined the distribution of thyroid-related autoantibodies in other autoimmune disorders. Methods: We tested sera from 234 patients with Graves' disease (GD), 130 with Hashimoto's thyroiditis (HT), 249 with other autoimmune diseases, and 50 healthy controls by enzyme-linked immunosorbent assay or radioimmunoassay. Results: Autoantibodies except TSH receptor antibody (Ab), anti-thyroglobulin (Tg) Ab and anti-thyroid peroxidase (TPO) Ab were not significantly prevalent in patients with AITD despite a significantly high elevation of thyroid-related Ab. Significant prevalence of autoantibodies related to AITD was observed in type 1 diabetes patients. Elevation of anti-Tg Ab was seen in patients with primary biliary cirrhosis (PBC) and autoimmune hepatitis (AIH), and anti-TPO Ab was elevated in patients with PBC. Although the prevalence of anti-acetylcholine receptor Ab and systemic lupus erythematosus (SLE)-related Ab was significant in AIH, primary Sjögren's syndrome (pSS)-related Ab were also found in both liver diseases. In myasthenia gravis (MG) patients, thyroid-related Ab and pSS-related Ab were detected in both MG groups, although SLE-related Ab were limited to the anti-muscle specific kinase Ab-positive MG patients. In patients with connective tissue diseases, anti-Tg Ab and anti-TPO Ab were significantly prevalent. Conclusion: Thyroid-related Ab were significantly elevated in all autoimmune diseases. Conversely, the elevations of Ab were not significant in the patients with AITD, suggesting a close relationship between AITD and other immune-mediated diseases.

Original languageEnglish
Pages (from-to)861-865
Number of pages5
JournalJournal of Endocrinological Investigation
Issue number10
Publication statusPublished - 2008 Oct
Externally publishedYes


  • Connective tissue diseases
  • Myasthenia gravis
  • Primary biliary cirrhosis
  • Thyroid disease
  • Type 1 diabetes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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