Prevention of asthma exacerbation with vaccination against influenza in winter season

Shin Watanabe; Yoshiharu Hoshiyama; Satoshi Matsukura; Fumio Kokubu; Masatsugu Kurokawa; Hideki Kuga; Mio Kawaguchi; Yosuke Inoue; Koushi Ieki; Miho Odaka; Shintaro Suzuki; Mie Aoki; Tomoko Akabane; Hiroko Takeuchi; Mitsuru Adachi; Takeshi Kawaguchi

doi:10.2332/allergolint.54.305

Prevention of asthma exacerbation with vaccination against influenza in winter season

Shin Watanabe, Yoshiharu Hoshiyama, Satoshi Matsukura, Fumio Kokubu, Masatsugu Kurokawa, Hideki Kuga, Mio Kawaguchi, Yosuke Inoue, Koushi Ieki, Miho Odaka, Shintaro Suzuki, Mie Aoki, Tomoko Akabane, Hiroko Takeuchi, Mitsuru Adachi, Takeshi Kawaguchi

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Background: Influenza virus is a major trigger of asthma exacerbation. Annual vaccination against influenza should be considered for asthmatics. However, the inoculation rates remain low. One reason may be the lack of evidence supporting the benefit of the vaccination for patients with asthma. Methods: We studied 115 adults with asthma in 2002-2003 and 67 in 2001-2002 and evaluated the effect of influenza vaccination on the prevention of asthma exacerbation during the winter season (December-March). Results: The rate of asthma exacerbation per person was significantly lower in asthmatics who received influenza vaccination (0.14 ± 0.4) during the 2002-2003 season than in asthmatics who did not (0.35 ± 0.61) (p = 0.037). During 2001-2002 season, the rate of asthma exacerbation in the vaccinated group (0.08 ± 0.41) appeared to be lower than that in the non-vaccinated group (0.27 ± 0.59). However, the difference between the two groups was not statistically significant (p = 0.143), presumably due to the low number of patients receiving vaccination. Severe adverse effects due to vaccination were not observed in the patients analyzed. Conclusions: Influenza vaccination during the winter season appears to be effective in the prevention of asthma exacerbation and should be recommended for patients with asthma.

Original language	English
Pages (from-to)	305-309
Number of pages	5
Journal	Allergology International
Volume	54
Issue number	2
DOIs	https://doi.org/10.2332/allergolint.54.305
Publication status	Published - 2005 Jun
Externally published	Yes

Keywords

Asthma
Exacerbation
Influenza
Vaccination
Viral infection

ASJC Scopus subject areas

Immunology and Allergy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2332/allergolint.54.305

Cite this

Watanabe, S., Hoshiyama, Y., Matsukura, S., Kokubu, F., Kurokawa, M., Kuga, H., Kawaguchi, M., Inoue, Y., Ieki, K., Odaka, M., Suzuki, S., Aoki, M., Akabane, T., Takeuchi, H., Adachi, M., & Kawaguchi, T. (2005). Prevention of asthma exacerbation with vaccination against influenza in winter season. Allergology International, 54(2), 305-309. https://doi.org/10.2332/allergolint.54.305

Watanabe, S, Hoshiyama, Y, Matsukura, S, Kokubu, F, Kurokawa, M, Kuga, H, Kawaguchi, M, Inoue, Y, Ieki, K, Odaka, M, Suzuki, S, Aoki, M, Akabane, T, Takeuchi, H, Adachi, M & Kawaguchi, T 2005, 'Prevention of asthma exacerbation with vaccination against influenza in winter season', Allergology International, vol. 54, no. 2, pp. 305-309. https://doi.org/10.2332/allergolint.54.305

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abstract = "Background: Influenza virus is a major trigger of asthma exacerbation. Annual vaccination against influenza should be considered for asthmatics. However, the inoculation rates remain low. One reason may be the lack of evidence supporting the benefit of the vaccination for patients with asthma. Methods: We studied 115 adults with asthma in 2002-2003 and 67 in 2001-2002 and evaluated the effect of influenza vaccination on the prevention of asthma exacerbation during the winter season (December-March). Results: The rate of asthma exacerbation per person was significantly lower in asthmatics who received influenza vaccination (0.14 ± 0.4) during the 2002-2003 season than in asthmatics who did not (0.35 ± 0.61) (p = 0.037). During 2001-2002 season, the rate of asthma exacerbation in the vaccinated group (0.08 ± 0.41) appeared to be lower than that in the non-vaccinated group (0.27 ± 0.59). However, the difference between the two groups was not statistically significant (p = 0.143), presumably due to the low number of patients receiving vaccination. Severe adverse effects due to vaccination were not observed in the patients analyzed. Conclusions: Influenza vaccination during the winter season appears to be effective in the prevention of asthma exacerbation and should be recommended for patients with asthma.",

keywords = "Asthma, Exacerbation, Influenza, Vaccination, Viral infection",

author = "Shin Watanabe and Yoshiharu Hoshiyama and Satoshi Matsukura and Fumio Kokubu and Masatsugu Kurokawa and Hideki Kuga and Mio Kawaguchi and Yosuke Inoue and Koushi Ieki and Miho Odaka and Shintaro Suzuki and Mie Aoki and Tomoko Akabane and Hiroko Takeuchi and Mitsuru Adachi and Takeshi Kawaguchi",

year = "2005",

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doi = "10.2332/allergolint.54.305",

language = "English",

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AU - Watanabe, Shin

AU - Hoshiyama, Yoshiharu

AU - Matsukura, Satoshi

AU - Kokubu, Fumio

AU - Kurokawa, Masatsugu

AU - Kuga, Hideki

AU - Kawaguchi, Mio

AU - Inoue, Yosuke

AU - Ieki, Koushi

AU - Odaka, Miho

AU - Suzuki, Shintaro

AU - Aoki, Mie

AU - Akabane, Tomoko

AU - Takeuchi, Hiroko

AU - Adachi, Mitsuru

AU - Kawaguchi, Takeshi

PY - 2005/6

Y1 - 2005/6

N2 - Background: Influenza virus is a major trigger of asthma exacerbation. Annual vaccination against influenza should be considered for asthmatics. However, the inoculation rates remain low. One reason may be the lack of evidence supporting the benefit of the vaccination for patients with asthma. Methods: We studied 115 adults with asthma in 2002-2003 and 67 in 2001-2002 and evaluated the effect of influenza vaccination on the prevention of asthma exacerbation during the winter season (December-March). Results: The rate of asthma exacerbation per person was significantly lower in asthmatics who received influenza vaccination (0.14 ± 0.4) during the 2002-2003 season than in asthmatics who did not (0.35 ± 0.61) (p = 0.037). During 2001-2002 season, the rate of asthma exacerbation in the vaccinated group (0.08 ± 0.41) appeared to be lower than that in the non-vaccinated group (0.27 ± 0.59). However, the difference between the two groups was not statistically significant (p = 0.143), presumably due to the low number of patients receiving vaccination. Severe adverse effects due to vaccination were not observed in the patients analyzed. Conclusions: Influenza vaccination during the winter season appears to be effective in the prevention of asthma exacerbation and should be recommended for patients with asthma.

AB - Background: Influenza virus is a major trigger of asthma exacerbation. Annual vaccination against influenza should be considered for asthmatics. However, the inoculation rates remain low. One reason may be the lack of evidence supporting the benefit of the vaccination for patients with asthma. Methods: We studied 115 adults with asthma in 2002-2003 and 67 in 2001-2002 and evaluated the effect of influenza vaccination on the prevention of asthma exacerbation during the winter season (December-March). Results: The rate of asthma exacerbation per person was significantly lower in asthmatics who received influenza vaccination (0.14 ± 0.4) during the 2002-2003 season than in asthmatics who did not (0.35 ± 0.61) (p = 0.037). During 2001-2002 season, the rate of asthma exacerbation in the vaccinated group (0.08 ± 0.41) appeared to be lower than that in the non-vaccinated group (0.27 ± 0.59). However, the difference between the two groups was not statistically significant (p = 0.143), presumably due to the low number of patients receiving vaccination. Severe adverse effects due to vaccination were not observed in the patients analyzed. Conclusions: Influenza vaccination during the winter season appears to be effective in the prevention of asthma exacerbation and should be recommended for patients with asthma.

KW - Asthma

KW - Exacerbation

KW - Influenza

KW - Vaccination

KW - Viral infection

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Prevention of asthma exacerbation with vaccination against influenza in winter season

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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