Prevention of asthma exacerbation with vaccination against influenza in winter season

Shin Watanabe, Yoshiharu Hoshiyama, Satoshi Matsukura, Fumio Kokubu, Masatsugu Kurokawa, Hideki Kuga, Mio Kawaguchi, Yosuke Inoue, Koushi Ieki, Miho Odaka, Shintaro Suzuki, Mie Aoki, Tomoko Akabane, Hiroko Takeuchi, Mitsuru Adachi, Takeshi Kawaguchi

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Background: Influenza virus is a major trigger of asthma exacerbation. Annual vaccination against influenza should be considered for asthmatics. However, the inoculation rates remain low. One reason may be the lack of evidence supporting the benefit of the vaccination for patients with asthma. Methods: We studied 115 adults with asthma in 2002-2003 and 67 in 2001-2002 and evaluated the effect of influenza vaccination on the prevention of asthma exacerbation during the winter season (December-March). Results: The rate of asthma exacerbation per person was significantly lower in asthmatics who received influenza vaccination (0.14 ± 0.4) during the 2002-2003 season than in asthmatics who did not (0.35 ± 0.61) (p = 0.037). During 2001-2002 season, the rate of asthma exacerbation in the vaccinated group (0.08 ± 0.41) appeared to be lower than that in the non-vaccinated group (0.27 ± 0.59). However, the difference between the two groups was not statistically significant (p = 0.143), presumably due to the low number of patients receiving vaccination. Severe adverse effects due to vaccination were not observed in the patients analyzed. Conclusions: Influenza vaccination during the winter season appears to be effective in the prevention of asthma exacerbation and should be recommended for patients with asthma.

Original languageEnglish
Pages (from-to)305-309
Number of pages5
JournalAllergology International
Issue number2
Publication statusPublished - 2005 Jun
Externally publishedYes


  • Asthma
  • Exacerbation
  • Influenza
  • Vaccination
  • Viral infection

ASJC Scopus subject areas

  • Immunology and Allergy


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