Preventive effect of lithospermate B from Salvia miltiorhiza on experimental hepatitis induced by carbon tetrachloride or D-galactosamine/lipopolysaccharide

Koji Hase; Rena Kasimu; Purusotam Basnet; Shigetoshi Kadota; Tsuneo Namba

doi:10.1055/s-2006-957596

Preventive effect of lithospermate B from Salvia miltiorhiza on experimental hepatitis induced by carbon tetrachloride or D-galactosamine/lipopolysaccharide

Koji Hase, Rena Kasimu, Purusotam Basnet, Shigetoshi Kadota, Tsuneo Namba

Research output: Contribution to journal › Article › peer-review

86 Citations (Scopus)

Abstract

The water extract from the root of Salvia miltiorhiza Bunge showed a protective effect on cultured rat hepatocytes against carbon tetrachloride (CCl₄)-induced necrosis. A further study was carried out to isolate the active constituent. Activity guided fractionation of the extract and chemical analysis gave us lithospermate B (a salt of lithospermic acid B), a tetramer of caffeic acid. Lithospermate B was also found to have a potent hepatoprotective activity in not only in vitro but also in vivo experimental liver injuries induced by CCl₄ or D-galactosamine (D-GalN)/lipopolysaccharide (LPS).

Original language	English
Pages (from-to)	22-26
Number of pages	5
Journal	Planta Medica
Volume	63
Issue number	1
DOIs	https://doi.org/10.1055/s-2006-957596
Publication status	Published - 1997 Mar 22
Externally published	Yes

Keywords

Labiatae
Salvia miltiorhiza
carbon tetrachloride
hepatoprotective effect
lipopolysaccharide
lithospermate B

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1055/s-2006-957596

Cite this

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title = "Preventive effect of lithospermate B from Salvia miltiorhiza on experimental hepatitis induced by carbon tetrachloride or D-galactosamine/lipopolysaccharide",

abstract = "The water extract from the root of Salvia miltiorhiza Bunge showed a protective effect on cultured rat hepatocytes against carbon tetrachloride (CCl4)-induced necrosis. A further study was carried out to isolate the active constituent. Activity guided fractionation of the extract and chemical analysis gave us lithospermate B (a salt of lithospermic acid B), a tetramer of caffeic acid. Lithospermate B was also found to have a potent hepatoprotective activity in not only in vitro but also in vivo experimental liver injuries induced by CCl4 or D-galactosamine (D-GalN)/lipopolysaccharide (LPS).",

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author = "Koji Hase and Rena Kasimu and Purusotam Basnet and Shigetoshi Kadota and Tsuneo Namba",

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T1 - Preventive effect of lithospermate B from Salvia miltiorhiza on experimental hepatitis induced by carbon tetrachloride or D-galactosamine/lipopolysaccharide

AU - Hase, Koji

AU - Kasimu, Rena

AU - Basnet, Purusotam

AU - Kadota, Shigetoshi

AU - Namba, Tsuneo

PY - 1997/3/22

Y1 - 1997/3/22

N2 - The water extract from the root of Salvia miltiorhiza Bunge showed a protective effect on cultured rat hepatocytes against carbon tetrachloride (CCl4)-induced necrosis. A further study was carried out to isolate the active constituent. Activity guided fractionation of the extract and chemical analysis gave us lithospermate B (a salt of lithospermic acid B), a tetramer of caffeic acid. Lithospermate B was also found to have a potent hepatoprotective activity in not only in vitro but also in vivo experimental liver injuries induced by CCl4 or D-galactosamine (D-GalN)/lipopolysaccharide (LPS).

AB - The water extract from the root of Salvia miltiorhiza Bunge showed a protective effect on cultured rat hepatocytes against carbon tetrachloride (CCl4)-induced necrosis. A further study was carried out to isolate the active constituent. Activity guided fractionation of the extract and chemical analysis gave us lithospermate B (a salt of lithospermic acid B), a tetramer of caffeic acid. Lithospermate B was also found to have a potent hepatoprotective activity in not only in vitro but also in vivo experimental liver injuries induced by CCl4 or D-galactosamine (D-GalN)/lipopolysaccharide (LPS).

KW - Labiatae

KW - Salvia miltiorhiza

KW - carbon tetrachloride

KW - hepatoprotective effect

KW - lipopolysaccharide

KW - lithospermate B

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Preventive effect of lithospermate B from Salvia miltiorhiza on experimental hepatitis induced by carbon tetrachloride or D-galactosamine/lipopolysaccharide

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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