Primary hepatic cancers with multiple pathologic features in a patient with hepatitis C: Report of a case

Go Oshima, Masahiro Shinoda, Minoru Tanabe, Yohei Masugi, Akihisa Ueno, Kiminori Takano, Minoru Kitago, Osamu Itano, Shigeyuki Kawachi, Kentaro Ohara, Masaya Oda, Akihiro Tanimoto, Michiie Sakamaoto, Yuko Kitagawa

Research output: Contribution to journalArticlepeer-review


We report a case of multiple primary hepatic cancers exhibiting different pathologic features coexisting in a patient with chronic hepatitis C. Computed tomography showed 2 tumors in segment 8, 20 mm (S8-A) and 5 mm (S8-B) in diameter, and a 10-mm tumor in segment 6 (S6). Based on the images, the S8-A lesion was diagnosed as cholangiocellular carcinoma or combined hepatocellular carcinoma and cholangiocarcinoma (combined HCC-CC). The other 2 tumors were diagnosed as HCC. The patient underwent partial resections of segments 6 and 8. We found 2 more tumors (S8-C was 6 mm in diameter and S8-D was 4 mm) in the resected segment 8 specimen. Histopathologic examination revealed that the S8-A and S8-C tumors were combined HCC-CC, the S8-B and S6 lesions were scirrhous HCC, and the S8-D tumor was an early HCC. This is a very rare case in which different hepatic cancers with multiple pathologic features coexisted.

Original languageEnglish
Pages (from-to)17-22
Number of pages6
JournalInternational Surgery
Issue number1
Publication statusPublished - 2012 Jan


  • Chronic hepatitis
  • Combined hepatocellular carcinoma and cholangiocarcinoma
  • Early hepatocellular carcinoma
  • Hepatitis C virus
  • Multicentric hepatocellular carcinoma
  • Multiple pathologic features
  • Scirrhous type of hepatocellular carcinoma

ASJC Scopus subject areas

  • Surgery


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