Primary malignant melanoma of the uterine cervix or vagina which were successfully treated with nivolumab

Mayuka Anko, Masaru Nakamura, Yusuke Kobayashi, Kosuke Tsuji, Sakura Nakada, Yoshio Nakamura, Takeru Funakoshi, Kouji Banno, Daisuke Aoki

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Primary malignant melanomas (MM) originating from the gynecological tract are rare. They respond poorly to immunotherapy when compared with cutaneous MM. This study reports two cases. The first is of a 54-year-old woman with a cervical amelanotic polypoid mass who was diagnosed as having stage IB1 cervical melanoma according to the International Federation of Gynecology and Obstetrics system. At 17 months post-surgery, a computed tomography examination revealed recurrence of a 68 mm pelvic tumor. The second case is of a 37-year-old woman with a 7 cm hemorrhagic mass on the vaginal wall. The patient was diagnosed as having stage IV vaginal melanoma according to the American Joint Committee on Cancer definition. Both patients received nivolumab therapy, programmed cell death receptor 1 monoclonal antibodies, and the tumors almost disappeared. These cases may add the possibility of using colposcopy with narrow-band imaging and positron-emission tomography to diagnose and evaluate primary MM.

Original languageEnglish
Pages (from-to)190-195
Number of pages6
JournalJournal of Obstetrics and Gynaecology Research
Issue number1
Publication statusPublished - 2020 Jan 1


  • colposcopy
  • melanoma
  • nivolumab
  • uterine cervix
  • vagina

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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