Primary Sclerosing Cholangitis Complicated with Aphthoid Colitis Difficult to Diagnose from IgG4-Related Sclerosing Cholangitis

Jin Imai; Hitoshi Ichikawa; Motoki Kaneko; Hiroyuki Ito; Shinji Takashimizu; Takayuki Shirai; Takuma Tajiri; Norihito Watanabe; Hidekazu Suzuki

doi:10.1159/000521538

Primary Sclerosing Cholangitis Complicated with Aphthoid Colitis Difficult to Diagnose from IgG4-Related Sclerosing Cholangitis

Jin Imai, Hitoshi Ichikawa, Motoki Kaneko, Hiroyuki Ito, Shinji Takashimizu, Takayuki Shirai, Takuma Tajiri, Norihito Watanabe, Hidekazu Suzuki

Center for Preventive Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

A 19-year-old man visited our hospital because of diarrhea and blood and liver dysfunction. Magnetic and endoscopic retrograde cholangiography revealed diffuse narrowing of the common biliary tract and intrahepatic biliary tract. A biopsy specimen from the narrowed area of the common biliary tract revealed IgG4-related sclerosing cholangitis (IgG4-SC). Colonoscopy showed multiple aphthoid colitis. He was treated with corticosteroids, and the levels of hepatobiliary enzymes, IgG, and IgG4 gradually decreased. This is an extremely rare case of colitis in which the patient had a phenotype of sclerosing cholangitis similar to IgG4-SC, which was finally diagnosed as primary sclerosing cholangitis.

Original language	English
Pages (from-to)	23-28
Number of pages	6
Journal	Case Reports in Gastroenterology
Volume	16
Issue number	1
DOIs	https://doi.org/10.1159/000521538
Publication status	Published - 2022 Feb 7

Keywords

Aphtoid colitis
IgG4-related sclerosing cholangitis
Primary sclerosing cholangitis

ASJC Scopus subject areas

Gastroenterology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000521538

Cite this

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title = "Primary Sclerosing Cholangitis Complicated with Aphthoid Colitis Difficult to Diagnose from IgG4-Related Sclerosing Cholangitis",

abstract = "A 19-year-old man visited our hospital because of diarrhea and blood and liver dysfunction. Magnetic and endoscopic retrograde cholangiography revealed diffuse narrowing of the common biliary tract and intrahepatic biliary tract. A biopsy specimen from the narrowed area of the common biliary tract revealed IgG4-related sclerosing cholangitis (IgG4-SC). Colonoscopy showed multiple aphthoid colitis. He was treated with corticosteroids, and the levels of hepatobiliary enzymes, IgG, and IgG4 gradually decreased. This is an extremely rare case of colitis in which the patient had a phenotype of sclerosing cholangitis similar to IgG4-SC, which was finally diagnosed as primary sclerosing cholangitis.",

keywords = "Aphtoid colitis, IgG4-related sclerosing cholangitis, Primary sclerosing cholangitis",

author = "Jin Imai and Hitoshi Ichikawa and Motoki Kaneko and Hiroyuki Ito and Shinji Takashimizu and Takayuki Shirai and Takuma Tajiri and Norihito Watanabe and Hidekazu Suzuki",

note = "Funding Information: This work was supported by Japan Society for the Promotion of Science (19K17413 to J.I.), Takeda Japan Medical Office Funded Research Grant 2019 (J.I.). Publisher Copyright: {\textcopyright} 2022 The Author(s). Published by S. Karger AG, Basel.",

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AU - Imai, Jin

AU - Ichikawa, Hitoshi

AU - Kaneko, Motoki

AU - Ito, Hiroyuki

AU - Takashimizu, Shinji

AU - Shirai, Takayuki

AU - Tajiri, Takuma

AU - Watanabe, Norihito

AU - Suzuki, Hidekazu

N1 - Funding Information: This work was supported by Japan Society for the Promotion of Science (19K17413 to J.I.), Takeda Japan Medical Office Funded Research Grant 2019 (J.I.). Publisher Copyright: © 2022 The Author(s). Published by S. Karger AG, Basel.

PY - 2022/2/7

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N2 - A 19-year-old man visited our hospital because of diarrhea and blood and liver dysfunction. Magnetic and endoscopic retrograde cholangiography revealed diffuse narrowing of the common biliary tract and intrahepatic biliary tract. A biopsy specimen from the narrowed area of the common biliary tract revealed IgG4-related sclerosing cholangitis (IgG4-SC). Colonoscopy showed multiple aphthoid colitis. He was treated with corticosteroids, and the levels of hepatobiliary enzymes, IgG, and IgG4 gradually decreased. This is an extremely rare case of colitis in which the patient had a phenotype of sclerosing cholangitis similar to IgG4-SC, which was finally diagnosed as primary sclerosing cholangitis.

AB - A 19-year-old man visited our hospital because of diarrhea and blood and liver dysfunction. Magnetic and endoscopic retrograde cholangiography revealed diffuse narrowing of the common biliary tract and intrahepatic biliary tract. A biopsy specimen from the narrowed area of the common biliary tract revealed IgG4-related sclerosing cholangitis (IgG4-SC). Colonoscopy showed multiple aphthoid colitis. He was treated with corticosteroids, and the levels of hepatobiliary enzymes, IgG, and IgG4 gradually decreased. This is an extremely rare case of colitis in which the patient had a phenotype of sclerosing cholangitis similar to IgG4-SC, which was finally diagnosed as primary sclerosing cholangitis.

KW - Aphtoid colitis

KW - IgG4-related sclerosing cholangitis

KW - Primary sclerosing cholangitis

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Primary Sclerosing Cholangitis Complicated with Aphthoid Colitis Difficult to Diagnose from IgG4-Related Sclerosing Cholangitis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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