Prognostic factors in dogs with protein-losing enteropathy

K. Nakashima, S. Hiyoshi, K. Ohno, K. Uchida, Y. Goto-Koshino, S. Maeda, N. Mizutani, A. Takeuchi, H. Tsujimoto

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)


Canine protein-losing enteropathy (PLE) is associated with severe gastrointestinal disorders and has a guarded to poor prognosis although little information is available regarding factors affecting prognosis. The purpose of this study was to identify the prognostic factors for survival of dogs with PLE. Ninety-two dogs diagnosed with PLE from 2006 to 2011 were included in a retrospective cohort study. Survival analysis was performed using the Kaplan-Meier method and log-rank test. Variables recorded at the time of diagnosis were statistically analysed for possible prognostic factors in a univariate and multivariate Cox proportional hazard model.In the multivariate analysis, the predictors for mortality in dogs with PLE were more highly scored in terms of canine inflammatory bowel disease activity index (CIBDAI) (P = 0.0003), clonal rearrangement of lymphocyte antigen receptor genes (P = 0.003), and elevation of blood urea nitrogen (BUN) (P = 0.03). Using histopathological diagnosis, both small- and large-cell lymphomas were associated with significantly shorter survival times than chronic enteritis (CE) and intestinal lymphangiectasia (IL). Normalization of CIBDAI and plasma albumin concentration within 50 days of initial treatment was associated with a longer survival time. In conclusion, CIBDAI, clonal rearrangement of lymphocyte antigen receptor genes, histopathological diagnosis, and response to initial treatments would be valuable in separating the underlying causes and could be important in predicting prognosis in dogs with PLE.

Original languageEnglish
Pages (from-to)28-32
Number of pages5
JournalVeterinary Journal
Issue number1
Publication statusPublished - 2015 Jul 1


  • Canine
  • Chronic enteropathy
  • Gastrointestinal lymphoma
  • Intestinal lymphangiectasia
  • Prognosis

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)


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