Prognostic factors of metastatic myxoid liposarcoma

Yusuke Shinoda, Eisuke Kobayashi, Hiroshi Kobayashi, Tomoaki Mori, Naofumi Asano, Robert Nakayama, Hideo Morioka, Shintaro Iwata, Tsukasa Yonemoto, Takeshi Ishii, Tohru Hiruma, Akira Kawai, Hirotaka Kawano

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9 Citations (Scopus)


Background: Myxoid liposarcoma (MLS) has the tendency to metastasize extrapulmonary. Although prognostic factors at the initial diagnosis of MLS have been reported, those at diagnosis of metastasis remain unclear. The purpose of this study was to investigate the prognostic factors for disease-specific survival at the initial diagnosis of metastasis. Methods: This retrospective observational study was conducted at three cancer centers and two university hospitals in Japan. Of 274 MLS patients pathologically diagnosed between 2001 and 2015, 48 metastatic patients were examined. Results: Lung metastases were detected in nine patients (18.8%) and extrapulmonary metastases in 45 (93.8%). Interval from primary diagnosis to the first metastasis was significantly shorter in patients with lung metastases than without (p = 0.007). Median disease-specific survival after diagnosis of metastases was 52.5 months in all patients. In multivariable analysis, liver metastasis (hazard ratio (HR), 2.71 [95% confidence interval (CI), 1.00-7.09]) and no evidence of disease (NED) achieved by radical treatment (resection with or without radiation therapy, or radiation therapy ≥60 Gy) or semi-radical (radiation therapy ≥40 Gy) treatment were significantly related to survival (HR, 0.36; 95%CI [0.13-0.95]). The number of metastases (odds ratio (OR), 0.44; 95%CI [0.25-0.78]) and abdominal/retroperitoneal metastases (OR, 0.09; 95%CI [0.008-0.95]) were the significant inhibitory factors of achieving NED. Conclusions: This is the first study to statistically demonstrate the importance of achieving NED with surgical resection or radiation therapy for longer survival in metastatic MLS patients. As number of metastases was a significant factor for achieving NED, early detection of metastases might be important.

Original languageEnglish
Article number883
JournalBMC cancer
Issue number1
Publication statusPublished - 2020 Sept 14


  • Metastasis
  • Myxoid liposarcoma
  • Prognostic factor

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research


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