Prognostic factors of Streptococcus pneumoniae infection in adults

Toru Hifumi, Seitaro Fujishima, Takayuki Abe, Nobuaki Kiriu, Junichi Inoue, Hiroshi Kato, Yuichi Koido, Kenya Kawakita, Yasuhiro Kuroda, Junichi Sasaki, Shingo Hori

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Objectives The mortality of severe sepsis has markedly decreased since the implementation of the Surviving Sepsis Campaign guidelines. The next logical step is to examine the necessity of individualized management guidelines for targeted therapy against specific bacteria. Streptococcus pneumoniae is the leading cause of community-acquired severe sepsis; however, little is known regarding the prognostic factors in adult patients with S pneumoniae sepsis. We aimed to identify prognostic factors in patients with S pneumoniae sepsis and to explore a subgroup of patients at high risk for death with detailed Sequential Organ Failure Assessment (SOFA) score analysis. Methods We retrospectively reviewed the records of patients with S pneumoniae infection treated between 1st January 2006 and 31st July 2012. We identified prognostic factors for 28-day mortality using univariate and multivariate logistic regression models. Results Of 171 patients (median age, 72 years) with S pneumoniae infection who were included in this study, the 28-day mortality was 17% (29/171). The SOFA score (odds ratio, 2.25; 95% confidence interval, 1.60-3.18; P <.001) and bacteremia (odds ratio, 19.0; 95% confidence interval, 4.06-90.20; P <.001) were identified as prognostic factors for the 28-day mortality. In a subgroup analysis with a cutoff value of the SOFA score determined by receiver operating characteristic analysis, patients with bacteremia and a SOFA score of at least 7 had a significantly higher mortality than did patients without bacteremia and a SOFA score lower than 7 (84% vs 0%, respectively). Conclusions Bacteremia and a SOFA score at least 7 were independent prognostic factors of poor outcome in S pneumoniae sepsis.

Original languageEnglish
Pages (from-to)202-206
Number of pages5
JournalAmerican Journal of Emergency Medicine
Issue number2
Publication statusPublished - 2016 Feb 1

ASJC Scopus subject areas

  • Emergency Medicine


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