Prognostic significance of CXCL12 expression in patients with colorectal carcinoma

Yuri Akishima-Fukasawa, Yukihiro Nakanishi, Yoshinori Ino, Yoshihiro Moriya, Yae Kanai, Setsuo Hirohashi

Research output: Contribution to journalArticlepeer-review

62 Citations (Scopus)


The present study investigated the protein expression level of CXCL12 in colorectal cancer and aimed to elucidate its association with prognosis. CXCL12 positivity in 50% or more of tumor cells was defined as high expression and that in less than 50% of the tumor cells as low expression. CXCL12+ tumor budding at the invasive front was divided into 2 grades: high with 10 or more budding foci per x200 field of view and low grade with fewer than 10 budding foci. Patients with high expression (72.7%) and high grade CXCL12+ tumor budding (43.0%) had significantly shorter survival than patients with low expression (P = .014) and low grade (P = .003), respectively. Patients with a combination of high expression and high grade had the worst outcome (P < .001). Our study demonstrated that CXCL12 expression in colorectal cancer cells and at sites of budding were significant prognostic factors. Furthermore, together with lymph node metastasis, a combination of both expression patterns was a more powerful independent prognostic factor.

Original languageEnglish
Pages (from-to)202-210
Number of pages9
JournalAmerican Journal of Clinical Pathology
Issue number2
Publication statusPublished - 2009 Aug
Externally publishedYes


  • CXCL12
  • Colorectal carcinoma
  • Immunohistochemistry
  • Invasive front
  • Prognosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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