Prognostic value of aortic root calcification volume on clinical outcomes after transcatheter balloon-expandable aortic valve implantation

Yusuke Watanabe, Thierry Lefèvre, Erik Bouvier, Takahide Arai, Kentaro Hayashida, Bernard Chevalier, Mauro Romano, Thomas Hovasse, Philippe Garot, Patrick Donzeau-Gouge, Arnaud Farge, Bertrand Cormier, Marie Claude Morice

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19 Citations (Scopus)


Background Few data are available about whether aortic root calcification may impact the outcomes after transcatheter aortic valve implantation (TAVI). Objectives This study sought to evaluate the impact of aortic root calcification volume on clinical outcome after TAVI with balloon expandable Edwards Sapien XT valve (Edwards Lifesciences, Irvine, California). Methods A total of 162 TAVI patients (aged 84.0 [Interquartile Range (IQR) 81.0-84.0] years, Logistic EuroSCORE 14.5 [IQR 9.8-25.1]) with preprocedural MDCT were studied. Aortic root calcification volume was measured by MDCT image and using the dedicated software for aortic valve assessment (the automated 3mensioTM Valves 5.1, sp1, 3mensio Pie Medical Imaging BV, Maastricht, the Netherlands). A valve calcification index (VCI) was defined as calcification volume (mm3)/body surface area (mm2). Results VCI was significantly higher among patients with 30-day mortality. A VCI threshold of 517.4 (area under the curve 0.69, 95% CI 0.50-0.87, P = 0.03) predicted a higher incidence of annulus rupture (9.1 vs. 0.9%, P = 0.02) and cardiac tamponade (12.7 vs. 1.9%, P <0.01), lower device success (83.6% vs. 95.3%, P <0.01) and 30-day survival rate (80.0% vs. 97.2%, P <0.01). Multivariate logistic regression analysis showed only ejection fraction and VCI were identified as independent predictors of 30-day mortality (Odds ratio 0.948 [95% confidence interval 0.909-0.988], P = 0.012, Odds ratio 1.003 [95% confidence interval 1.001-1.005], P = 0.013, respectively). Conclusions Significantly worse acute clinical outcomes after Edwards valve implantation were observed in patients with large amount of aortic annulus calcifications quantitatively measured by dedicated MDCT software. Application of VCI may prove helpful in prediction of clinical outcomes after TAVI.

Original languageEnglish
Pages (from-to)1105-1113
Number of pages9
JournalCatheterization and Cardiovascular Interventions
Issue number6
Publication statusPublished - 2015 Nov 15


  • annulus rupture
  • balloon-expandable valve
  • calcification
  • multislice computed tomography
  • transcatheter aortic valve implantation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging


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