Prognostic Value of the Lymphocyte-to-Monocyte Ratio in Patients with Parotid Gland Carcinoma

Takuya Mikoshiba; Hiroyuki Ozawa; Yoshihiro Watanabe; Mariko Sekimizu; Shin Saito; Keisuke Yoshihama; Shintaro Nakamura; Yorihisa Imanishi; Kaori Kameyama; Kaoru Ogawa

doi:10.1002/lary.28934

Prognostic Value of the Lymphocyte-to-Monocyte Ratio in Patients with Parotid Gland Carcinoma

Takuya Mikoshiba, Hiroyuki Ozawa, Yoshihiro Watanabe, Mariko Sekimizu, Shin Saito, Keisuke Yoshihama, Shintaro Nakamura, Yorihisa Imanishi, Kaori Kameyama, Kaoru Ogawa

Department of Otorhinolaryngology

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Objective: Previous studies have evaluated various markers as prognostic predictors in patients with many types of cancers. However, the influence of such factors on the outcomes of patients with parotid gland carcinoma (PGC) is unknown. This study investigated the roles of alternative markers in the prognoses of patients with PGC. Methods: Overall, 101 patients who underwent curative treatment for PGC were retrospectively evaluated, and their 5-year overall and disease-free survival rates were calculated. The prognostic values of clinical and pathologic factors were determined. Results: The 5-year overall and disease-free survival rates were 73.1% and 62.8%, respectively. Multivariate analysis revealed that a low lymphocyte-to-monocyte ratio (LMR), high T classification, high N classification, and perineural invasion were independent predictors of poor prognosis. Conclusions: Thus, we identified LMR as an independent prognostic factor for patients with PGC. Patients with low LMRs who are amenable to treatment may require adjuvant treatment to improve their prognoses. Level of Evidence: 4 Laryngoscope, 131:E864–E869, 2021.

Original language	English
Pages (from-to)	E864-E869
Journal	Laryngoscope
Volume	131
Issue number	3
DOIs	https://doi.org/10.1002/lary.28934
Publication status	Published - 2021 Mar

Keywords

Disease free survival, lymphocyte-to-monocyte ratio, overall survival, parotid gland carcinoma, prognostic factor.

ASJC Scopus subject areas

Otorhinolaryngology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/lary.28934

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title = "Prognostic Value of the Lymphocyte-to-Monocyte Ratio in Patients with Parotid Gland Carcinoma",

abstract = "Objective: Previous studies have evaluated various markers as prognostic predictors in patients with many types of cancers. However, the influence of such factors on the outcomes of patients with parotid gland carcinoma (PGC) is unknown. This study investigated the roles of alternative markers in the prognoses of patients with PGC. Methods: Overall, 101 patients who underwent curative treatment for PGC were retrospectively evaluated, and their 5-year overall and disease-free survival rates were calculated. The prognostic values of clinical and pathologic factors were determined. Results: The 5-year overall and disease-free survival rates were 73.1% and 62.8%, respectively. Multivariate analysis revealed that a low lymphocyte-to-monocyte ratio (LMR), high T classification, high N classification, and perineural invasion were independent predictors of poor prognosis. Conclusions: Thus, we identified LMR as an independent prognostic factor for patients with PGC. Patients with low LMRs who are amenable to treatment may require adjuvant treatment to improve their prognoses. Level of Evidence: 4 Laryngoscope, 131:E864–E869, 2021.",

keywords = "Disease free survival, lymphocyte-to-monocyte ratio, overall survival, parotid gland carcinoma, prognostic factor.",

author = "Takuya Mikoshiba and Hiroyuki Ozawa and Yoshihiro Watanabe and Mariko Sekimizu and Shin Saito and Keisuke Yoshihama and Shintaro Nakamura and Yorihisa Imanishi and Kaori Kameyama and Kaoru Ogawa",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors. The Laryngoscope published by Wiley Periodicals LLC. on behalf of The American Laryngological, Rhinological and Otological Society, Inc.",

year = "2021",

month = mar,

doi = "10.1002/lary.28934",

language = "English",

volume = "131",

pages = "E864--E869",

journal = "Laryngoscope",

issn = "0023-852X",

publisher = "John Wiley and Sons Inc.",

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T1 - Prognostic Value of the Lymphocyte-to-Monocyte Ratio in Patients with Parotid Gland Carcinoma

AU - Mikoshiba, Takuya

AU - Ozawa, Hiroyuki

AU - Watanabe, Yoshihiro

AU - Sekimizu, Mariko

AU - Saito, Shin

AU - Yoshihama, Keisuke

AU - Nakamura, Shintaro

AU - Imanishi, Yorihisa

AU - Kameyama, Kaori

AU - Ogawa, Kaoru

PY - 2021/3

Y1 - 2021/3

N2 - Objective: Previous studies have evaluated various markers as prognostic predictors in patients with many types of cancers. However, the influence of such factors on the outcomes of patients with parotid gland carcinoma (PGC) is unknown. This study investigated the roles of alternative markers in the prognoses of patients with PGC. Methods: Overall, 101 patients who underwent curative treatment for PGC were retrospectively evaluated, and their 5-year overall and disease-free survival rates were calculated. The prognostic values of clinical and pathologic factors were determined. Results: The 5-year overall and disease-free survival rates were 73.1% and 62.8%, respectively. Multivariate analysis revealed that a low lymphocyte-to-monocyte ratio (LMR), high T classification, high N classification, and perineural invasion were independent predictors of poor prognosis. Conclusions: Thus, we identified LMR as an independent prognostic factor for patients with PGC. Patients with low LMRs who are amenable to treatment may require adjuvant treatment to improve their prognoses. Level of Evidence: 4 Laryngoscope, 131:E864–E869, 2021.

AB - Objective: Previous studies have evaluated various markers as prognostic predictors in patients with many types of cancers. However, the influence of such factors on the outcomes of patients with parotid gland carcinoma (PGC) is unknown. This study investigated the roles of alternative markers in the prognoses of patients with PGC. Methods: Overall, 101 patients who underwent curative treatment for PGC were retrospectively evaluated, and their 5-year overall and disease-free survival rates were calculated. The prognostic values of clinical and pathologic factors were determined. Results: The 5-year overall and disease-free survival rates were 73.1% and 62.8%, respectively. Multivariate analysis revealed that a low lymphocyte-to-monocyte ratio (LMR), high T classification, high N classification, and perineural invasion were independent predictors of poor prognosis. Conclusions: Thus, we identified LMR as an independent prognostic factor for patients with PGC. Patients with low LMRs who are amenable to treatment may require adjuvant treatment to improve their prognoses. Level of Evidence: 4 Laryngoscope, 131:E864–E869, 2021.

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Prognostic Value of the Lymphocyte-to-Monocyte Ratio in Patients with Parotid Gland Carcinoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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