Progress in myocardial regeneration and cell transplantation

Keiichi Fukuda

Research output: Contribution to journalReview articlepeer-review

45 Citations (Scopus)


Embryonic stem cells and bone marrow mesenchymal stem cells can be induced to differentiate into cardiomyocytes. Techniques to purify and transplant regenerated cardiomyocytes have been developed, and transplanted regenerated cardiomyocytes are capable of residing in the heart of recipients for long periods. Advances in tissue engineering technology have enabled the production of cardiomyocyte cell sheets for transplantation treatment of heart failure, without the need for a donor, and this has now reached the preclinical stage. The treatment of heart failure using cytokines to mobilize stem cells has also been explored.

Original languageEnglish
Pages (from-to)1431-1446
Number of pages16
JournalCirculation Journal
Issue number12
Publication statusPublished - 2005 Dec


  • Bone marrow mesenchymal stem cells
  • Cardiomyocytes
  • Cell transplantation
  • Embryonic stem cells
  • Heart failure
  • Regenerative medicine

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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