Progression of logopenic variant primary progressive aphasia to apraxia and semantic memory deficits

Michitaka Funayama, Yoshitaka Nakagawa, Yoko Yamaya, Fumihiro Yoshino, Masaru Mimura, Motoichiro Kato

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


Background: Due to the nature of neurodegenerative disorders, patients with primary progressive aphasia develop cognitive impairment other than aphasia as the disorder progresses. The progression of logopenic variant primary progressive aphasia (lvPPA), however, has not been well described. In particular, praxic disorders and semantic memory deficits have rarely been reported. Case presentations: We report three patients in the initial stage of lvPPA who subsequently developed apraxia in the middle stage and developed clinically evident semantic memory deficits in the advanced stages.Conclusions: The present case series suggests that some patients with lvPPA develop an atypical type of dementia with apraxia and semantic memory deficits, suggesting that these cases should be classified as a type of early-onset Alzheimer's disease.

Original languageEnglish
Article number158
JournalBMC Neurology
Publication statusPublished - 2013 Nov 1
Externally publishedYes


  • Alzheimer's disease
  • Apraxia
  • Logopenic variant primary progressive aphasia
  • Semantic memory deficit

ASJC Scopus subject areas

  • Clinical Neurology


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