Proliferation of neuroblasts in the adult brain: Role of diversin

Yuki Hirota, Kazunobu Sawamoto

Research output: Chapter in Book/Report/Conference proceedingChapter


The subventricular zone (SVZ) is the largest neurogenic region in the adult rodent brain. In this region, new neurons that originate from neural stem cells (NSCs) migrate to the olfactory bulb, where they mature into interneurons. During neurogenesis, the proliferation of NSCs and neuronal progenitor cells are precisely regulated by multiple signaling pathways to maintain homeostasis. Wnt signaling is one mechanism that controls the proliferation of SVZ cells. In addition to NSCs and progenitor cells, the migration of new neurons (neuroblasts) also maintains the proliferative capacity. Recently, Diversin, which is a component of the Wnt signaling pathway, has been shown to promote the proliferation of neuroblasts in the SVZ. Neuroblast proliferation may be an important step in regenerative responses to brain injury and in normal physio–logical neurogenesis.

Original languageEnglish
Title of host publicationTumors of the Central Nervous System, Volume 9
Subtitle of host publicationLymphoma, Supratentorial Tumors, Glioneuronal Tumors, Gangliogliomas, Neuroblastoma in Adults, Astrocytomas, Ependymomas, Hemangiomas, and Craniopharyngiomas
PublisherSpringer Netherlands
Number of pages7
ISBN (Electronic)9789400754881
ISBN (Print)9789400754874
Publication statusPublished - 2012 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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