Propolis protects pancreatic β-cells against the toxicity of streptozotocin (STZ)

K. Matsushige; P. Basnet; K. Hase; S. Kadota; K. Tanaka; T. Namba

doi:10.1016/S0944-7113(96)80037-7

Propolis protects pancreatic β-cells against the toxicity of streptozotocin (STZ)

K. Matsushige, P. Basnet, K. Hase, S. Kadota, K. Tanaka, T. Namba

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Propolis is a glue, prepared by honeybees from plant materials to stick their hives on the beehive wall. It has gained popularity in Japan as a healthy drink and people believe that propolis can cure inflammation, heart diseases and even diabetes and cancer. We have evaluated the β-cell protective effect of propolis against the toxicity of streptozotocin (STZ) in rats. The water extract of propolis (PWE) completely protected β-cell destruction against STZ toxicity. The protective effect of PWE was found to be almost equal to that of nicotinamide. PWE also inhibited the interleukin-1 ß(IL-I ß) generation from human leukocytes. The free radical scavenging activity to-gether with IL-I ßand nitric oxide (NO) synthase inhibitory activities are thought to be the prime factors for the protective effect of PWE against STZ toxicity.

Original language	English
Pages (from-to)	203-209
Number of pages	7
Journal	Phytomedicine
Volume	3
Issue number	2
DOIs	https://doi.org/10.1016/S0944-7113(96)80037-7
Publication status	Published - 1996 Sept
Externally published	Yes

Keywords

Free radical scavenger
Interleukin-1 β
Nitric oxide
Propolis
Streptozotocin

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0944-7113(96)80037-7

Cite this

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title = "Propolis protects pancreatic β-cells against the toxicity of streptozotocin (STZ)",

abstract = "Propolis is a glue, prepared by honeybees from plant materials to stick their hives on the beehive wall. It has gained popularity in Japan as a healthy drink and people believe that propolis can cure inflammation, heart diseases and even diabetes and cancer. We have evaluated the β-cell protective effect of propolis against the toxicity of streptozotocin (STZ) in rats. The water extract of propolis (PWE) completely protected β-cell destruction against STZ toxicity. The protective effect of PWE was found to be almost equal to that of nicotinamide. PWE also inhibited the interleukin-1 {\ss}(IL-I {\ss}) generation from human leukocytes. The free radical scavenging activity to-gether with IL-I {\ss}and nitric oxide (NO) synthase inhibitory activities are thought to be the prime factors for the protective effect of PWE against STZ toxicity.",

keywords = "Free radical scavenger, Interleukin-1 β, Nitric oxide, Propolis, Streptozotocin",

author = "K. Matsushige and P. Basnet and K. Hase and S. Kadota and K. Tanaka and T. Namba",

year = "1996",

month = sep,

doi = "10.1016/S0944-7113(96)80037-7",

language = "English",

volume = "3",

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journal = "Phytomedicine",

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publisher = "Urban und Fischer Verlag Jena",

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}

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T1 - Propolis protects pancreatic β-cells against the toxicity of streptozotocin (STZ)

AU - Matsushige, K.

AU - Basnet, P.

AU - Hase, K.

AU - Kadota, S.

AU - Tanaka, K.

AU - Namba, T.

PY - 1996/9

Y1 - 1996/9

N2 - Propolis is a glue, prepared by honeybees from plant materials to stick their hives on the beehive wall. It has gained popularity in Japan as a healthy drink and people believe that propolis can cure inflammation, heart diseases and even diabetes and cancer. We have evaluated the β-cell protective effect of propolis against the toxicity of streptozotocin (STZ) in rats. The water extract of propolis (PWE) completely protected β-cell destruction against STZ toxicity. The protective effect of PWE was found to be almost equal to that of nicotinamide. PWE also inhibited the interleukin-1 ß(IL-I ß) generation from human leukocytes. The free radical scavenging activity to-gether with IL-I ßand nitric oxide (NO) synthase inhibitory activities are thought to be the prime factors for the protective effect of PWE against STZ toxicity.

AB - Propolis is a glue, prepared by honeybees from plant materials to stick their hives on the beehive wall. It has gained popularity in Japan as a healthy drink and people believe that propolis can cure inflammation, heart diseases and even diabetes and cancer. We have evaluated the β-cell protective effect of propolis against the toxicity of streptozotocin (STZ) in rats. The water extract of propolis (PWE) completely protected β-cell destruction against STZ toxicity. The protective effect of PWE was found to be almost equal to that of nicotinamide. PWE also inhibited the interleukin-1 ß(IL-I ß) generation from human leukocytes. The free radical scavenging activity to-gether with IL-I ßand nitric oxide (NO) synthase inhibitory activities are thought to be the prime factors for the protective effect of PWE against STZ toxicity.

KW - Free radical scavenger

KW - Interleukin-1 β

KW - Nitric oxide

KW - Propolis

KW - Streptozotocin

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DO - 10.1016/S0944-7113(96)80037-7

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SN - 0944-7113

VL - 3

SP - 203

EP - 209

JO - Phytomedicine

JF - Phytomedicine

IS - 2

ER -

Propolis protects pancreatic β-cells against the toxicity of streptozotocin (STZ)

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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