Propolis protects pancreatic β-cells against the toxicity of streptozotocin (STZ)

K. Matsushige, P. Basnet, K. Hase, S. Kadota, K. Tanaka, T. Namba

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)


Propolis is a glue, prepared by honeybees from plant materials to stick their hives on the beehive wall. It has gained popularity in Japan as a healthy drink and people believe that propolis can cure inflammation, heart diseases and even diabetes and cancer. We have evaluated the β-cell protective effect of propolis against the toxicity of streptozotocin (STZ) in rats. The water extract of propolis (PWE) completely protected β-cell destruction against STZ toxicity. The protective effect of PWE was found to be almost equal to that of nicotinamide. PWE also inhibited the interleukin-1 ß(IL-I ß) generation from human leukocytes. The free radical scavenging activity to-gether with IL-I ßand nitric oxide (NO) synthase inhibitory activities are thought to be the prime factors for the protective effect of PWE against STZ toxicity.

Original languageEnglish
Pages (from-to)203-209
Number of pages7
Issue number2
Publication statusPublished - 1996 Sept
Externally publishedYes


  • Free radical scavenger
  • Interleukin-1 β
  • Nitric oxide
  • Propolis
  • Streptozotocin

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine


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