Proposed protocol for treatment of severe periodontitis without platelet transfusion in patients with aplastic anemia: a case report

Satoru Morikawa, Kazuya Watanabe, Satoshi Usuda, Yoko Miyashita, Taneaki Nakagawa

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Background: Aplastic anemia is an intractable disease characterized by pancytopenia, susceptibility to infection, and difficulty in achieving hemostasis. In patients with severe periodontal disease and aplastic anemia, spontaneous bleeding from the gingival tissue due to thrombocytopenia and during brushing is common, which may further exacerbate dental issues. Comprehensive periodontal treatment for patients with aplastic anemia is highly challenging and requires collaboration with a hematologist. Here, we discuss the case of a patient with aplastic anemia and severe periodontitis who was successfully treated in collaboration with our hematology department. Case presentation: A 36-year-old Japanese woman with chief complaints of spontaneous gingival bleeding, pain, and increasing tooth mobility consulted our department. She had developed pancytopenia at age 11 years and was later diagnosed with aplastic anemia, making her susceptible to infection due to leukopenia. The results of the initial periodontal examination led to a diagnosis of severe generalized periodontitis (generalized stage IV grade C periodontitis) caused by leukopenia and poor oral hygiene. We adopted a comprehensive treatment plan, including invasive dental procedures. The patient exhibited no postoperative bleeding due to aplastic anemia-induced thrombocytopenia and experienced a good outcome. Conclusions: Both physicians and dentists should be aware that immunocompromised patients with aplastic anemia are at risk of developing severe periodontitis with severe alveolar bone resorption if the condition is combined with poor oral hygiene. Even in the presence of aplastic anemia, patients with severe periodontitis can undergo comprehensive dental treatment, including dental extraction and periodontal surgery, if bleeding and susceptibility to infection are controlled. This requires the cooperation of the patient and hematologists and can ultimately contribute to improving the patient’s quality of life.

Original languageEnglish
Article number581
JournalJournal of Medical Case Reports
Issue number1
Publication statusPublished - 2021 Dec


  • Aplastic anemia
  • Dentistry
  • Hematology
  • Oral medicine
  • Severe periodontitis

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Proposed protocol for treatment of severe periodontitis without platelet transfusion in patients with aplastic anemia: a case report'. Together they form a unique fingerprint.

Cite this