TY - JOUR
T1 - Prospective comparison of various radiological response criteria and pathological response to preoperative chemotherapy and survival in operable high-grade soft tissue sarcomas in the Japan Clinical Oncology Group study JCOG0304
AU - Tanaka, Kazuhiro
AU - Ogawa, Gakuto
AU - Mizusawa, Junki
AU - Naka, Norifumi
AU - Kawai, Akira
AU - Takahashi, Mitsuru
AU - Hiruma, Toru
AU - Matsumoto, Yoshihiro
AU - Tsuchiya, Hiroyuki
AU - Nakayama, Robert
AU - Hatano, Hiroshi
AU - Emori, Makoto
AU - Hosaka, Masami
AU - Yoshida, Yukihiro
AU - Toguchida, Junya
AU - Abe, Satoshi
AU - Asanuma, Kunihiro
AU - Yokoyama, Ryohei
AU - Hiraga, Hiroaki
AU - Yonemoto, Tsukasa
AU - Morii, Takeshi
AU - Matsumoto, Seiichi
AU - Nagano, Akihito
AU - Yoshikawa, Hideki
AU - Fukuda, Haruhiko
AU - Ozaki, Toshifumi
AU - Iwamoto, Yukihide
N1 - Funding Information:
This work was supported in part by National Cancer Center Research and Development Fund (23-A-16, 23-A-20, 26-A-4, 29-A-3), the Grants-in-Aid for Cancer Research (14S-1, 14S-4, 17S-4, 17S-5, 20S-4 and 20S-6), the Health and Labour Sciences Research Grant (H14-Gan-033, H17-Gan-006) from the Ministry of Health, Labour and Welfare, and Applied Research for Innovative Treatment of Cancer (H26-084) from the Ministry of Health, Labour and Welfare, and the Agency for Medical Research and Development, Japan. We appreciate the participation of the patients and their families. The authors are grateful to the members of the Japan Clinical Oncology Group (JCOG) Data Center and JCOG Operations Office for their support in preparing the manuscript (Tomohiro Kadota, Kiyo Tanaka, and Junko Eba).
Funding Information:
This work was supported in part by National Cancer Center Research and Development Fund (23-A-16, 23-A-20, 26-A-4, 29-A-3), the Grants-in-Aid for Cancer Research (14S-1, 14S-4, 17S-4, 17S-5, 20S-4 and 20S-6), the Health and Labour Sciences Research Grant (H14-Gan-033, H17-Gan-006) from the Ministry of Health, Labour and Welfare, and Applied Research for Innovative Treatment of Cancer (H26–084) from the Ministry of Health, Labour and Welfare, and the Agency for Medical Research and Development, Japan.
Publisher Copyright:
© 2018 The Author(s).
PY - 2018/8/10
Y1 - 2018/8/10
N2 - Background: Soft tissue sarcomas (STS) are rare malignant tumors. The efficacy of preoperative chemotherapy for STS is evaluated using various tumor size-based radiological response criteria. However, it is still unclear which set of criteria would show the best association with pathological response and survival of the patients with STS. Methods: We compared radiological responses to preoperative chemotherapy for operable STS by the Response Evaluation Criteria in Solid Tumors (RECIST), modified RECIST, World Health Organization criteria, Japanese Orthopaedic Association criteria, and modified Choi criteria and analyzed the association with pathological response and survival using the data from the Japan Clinical Oncology Group (JCOG) study JCOG0304, a phase II clinical trial evaluating the efficacy of perioperative chemotherapy for STS in the extremities. Results: Seventy eligible patients in JCOG0304 were analyzed. The results demonstrated that none of the size-based radiological response criteria showed significant association with pathological response to preoperative chemotherapy for STS. The difference between overall survival of the patients assessed as partial response and stable disease/progressive disease by RECIST was not significant (hazard ratio 1.37, p = 0.63), and calculated C-index was 0.50. All other response criteria also could not exhibit significant association between radiological responses and survival. Conclusion: In the present study, none of the radiological response criteria analyzed demonstrated association of response to preoperative chemotherapy with pathological response or survival of the patients with operable STS. Further prospective investigation is required to develop criteria to evaluate not only tumor shrinkage but biological effects of preoperative chemotherapy for the patients with localized STS.
AB - Background: Soft tissue sarcomas (STS) are rare malignant tumors. The efficacy of preoperative chemotherapy for STS is evaluated using various tumor size-based radiological response criteria. However, it is still unclear which set of criteria would show the best association with pathological response and survival of the patients with STS. Methods: We compared radiological responses to preoperative chemotherapy for operable STS by the Response Evaluation Criteria in Solid Tumors (RECIST), modified RECIST, World Health Organization criteria, Japanese Orthopaedic Association criteria, and modified Choi criteria and analyzed the association with pathological response and survival using the data from the Japan Clinical Oncology Group (JCOG) study JCOG0304, a phase II clinical trial evaluating the efficacy of perioperative chemotherapy for STS in the extremities. Results: Seventy eligible patients in JCOG0304 were analyzed. The results demonstrated that none of the size-based radiological response criteria showed significant association with pathological response to preoperative chemotherapy for STS. The difference between overall survival of the patients assessed as partial response and stable disease/progressive disease by RECIST was not significant (hazard ratio 1.37, p = 0.63), and calculated C-index was 0.50. All other response criteria also could not exhibit significant association between radiological responses and survival. Conclusion: In the present study, none of the radiological response criteria analyzed demonstrated association of response to preoperative chemotherapy with pathological response or survival of the patients with operable STS. Further prospective investigation is required to develop criteria to evaluate not only tumor shrinkage but biological effects of preoperative chemotherapy for the patients with localized STS.
KW - Pathological response
KW - Preoperative chemotherapy
KW - Radiological response criteria
KW - Soft tissue sarcoma
KW - Survival
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U2 - 10.1186/s12957-018-1462-y
DO - 10.1186/s12957-018-1462-y
M3 - Article
C2 - 30097070
AN - SCOPUS:85051497885
SN - 1477-7819
VL - 16
JO - World Journal of Surgical Oncology
JF - World Journal of Surgical Oncology
IS - 1
M1 - 162
ER -