Prospective observational study of clinical course after stopping inhaled corticosteroids in child asthma

Akira Akasawa, Tomoko Suda, Masayuki Akashi, Masami Narita, Yukihiro Ohya, Akemi Manki, Hiroko Watanabe, Miyuki Kumaki, Kenji Matsumoto, Hirohisa Saito

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Background: Prospective study was carried out to observe the clinical course and find out the clinical index to predict the outcome after stopping of inhaled corticosteroids (ICS). Subjects: One hundred twelve asthmatic children (aged 12.9 ± 9.6 years old) who were totally controlled with 100μg/day of inhaled corticosteroids and have not experienced asthma symptom over 3 months, were enrolled. Methods: Patients with over PC 20 0.5mg/mL of methacholine challenge test (MCT) were recommended to stop ICS therapy. Clinical course, lung function and bronchial hyperreactivity were followed at 7, 16 and 24 months after stopping of ICS. Results: Eighty-one percent of 63 patients followed up to 24 months run on as symptom less than one time per month without remarkable change of lung function. PC 20 in group of no asthma symptom during 24 months (group A) decreased weakly. That of other groups decreased remarkably. Days using ICS and plasma IgE antibody at stopping of ICS were different in clinical course at 24 months after stopping ICS. Conclusion: Over 80% of totally controlled asthmatic children with MCT PC 20 over 0.5mg/mL could stop ICS therapy and run on without relapse.

Original languageEnglish
Pages (from-to)1407-1417
Number of pages11
JournalJapanese Journal of Allergology
Issue number10
Publication statusPublished - 2009
Externally publishedYes


  • Child asthma
  • Inhaled corticosteroids
  • Prospective study
  • Step down

ASJC Scopus subject areas

  • General Medicine


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