TY - JOUR
T1 - Protection of ischemie myocardium by inhibition of contracture in isolated rat heart
AU - Tani, Masato
AU - Hasegawa, Hiroshi
AU - Suganuma, Yukako
AU - Shinmura, Ken
AU - Kayashi, Yoko
AU - Nakamura, Yoshiro
PY - 1996
Y1 - 1996
N2 - Protection of the isch-emic myocardium by pretreatment with a high dose of 2,3-butanedione monoxime (: BDM is attributed to the enhancement of glycolytic ATP production rather than to the inhibition of contracture during mild ischemia. Our objective was to investigate whether the inhibition of contracture would protect the arrested heart during prolonged ischemia. Isolated perfused rat hearts were subjected to 30 min of low-flow ischemia followed by reperfusion. Ischémie hearts were treated with BDM 5 mmol/1 after beating stopped. BDM ameliorated the increase in intraventricular pressure after ischemia without significant changes in ATP levels and with a decreased accumulation of lactate. BDM treatment accelerated the recovery of function and high-energy phosphates with reduced myocardial Ca2+ overload. The results of this study suggested that inhibition of contracture can protect the heart from ischemia-reperfusion injury.
AB - Protection of the isch-emic myocardium by pretreatment with a high dose of 2,3-butanedione monoxime (: BDM is attributed to the enhancement of glycolytic ATP production rather than to the inhibition of contracture during mild ischemia. Our objective was to investigate whether the inhibition of contracture would protect the arrested heart during prolonged ischemia. Isolated perfused rat hearts were subjected to 30 min of low-flow ischemia followed by reperfusion. Ischémie hearts were treated with BDM 5 mmol/1 after beating stopped. BDM ameliorated the increase in intraventricular pressure after ischemia without significant changes in ATP levels and with a decreased accumulation of lactate. BDM treatment accelerated the recovery of function and high-energy phosphates with reduced myocardial Ca2+ overload. The results of this study suggested that inhibition of contracture can protect the heart from ischemia-reperfusion injury.
KW - 2,3-butanedione monoxime
KW - Energy-sparing effect
KW - Negative inotropic effect
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M3 - Article
C2 - 8997312
AN - SCOPUS:0030477192
SN - 0002-9513
VL - 271
SP - H2515-H2519
JO - American Journal of Physiology
JF - American Journal of Physiology
IS - 6 PART 2
ER -