Protective role of HSP70 against various gastrointestinal diseases

Tohru Mizushima

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


It is well known that expression of heat shock proteins (HSPs) is induced by various stressors in order to confer protection against such stressors. Stressor-induced tissue damage is involved in various diseases, especially gastrointestinal diseases. In this article, I review our recent work on protective role of HSP70 against gastrointestinal diseases. We obtained genetic evidences that HSP70 is protective against gastric ulcer, inflammatory bowel disease-related colitis and lesions of small intestine. We also suggested that HSP70 could stimulate the ulcer healing. Furthermore, we found that geranylgeranylacetone (non-toxic HSP-inducer) is effective against these diseases. Based on these observations, I propose that non-toxic HSP-inducers are therapeutically beneficial for these diseases.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalCurrent Opinion in Pharmacology
Publication statusPublished - 2014 Dec

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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