TY - JOUR
T1 - Proteinuria is a prognostic marker for cardiovascular mortality
T2 - NIPPON DATA 80, 1980-1999
AU - Tanihara, Shinichi
AU - Hayakawa, Takehito
AU - Oki, Izumi
AU - Nakamura, Yosikazu
AU - Sakata, Kiyomi
AU - Okayama, Akira
AU - Fujita, Yasuyuki
AU - Ueshima, Hirotsugu
AU - Iimura, Osamu
AU - Omae, Teruo
AU - Ueda, Kazuo
AU - Yanagawa, Hiroshi
AU - Kodama, Kazunori
AU - Kasagi, Fumiyoshi
AU - Okamura, Tomonori
AU - Kita, Yoshikuni
AU - Saito, Shigeyuki
AU - Sakata, Kiyomi
AU - Tanihara, Shinichi
AU - Horibe, Hiroshi
AU - Minowa, Masumi
AU - Takeuchi, Toshihiro
AU - Hasebe, Mitsuru
AU - Kusano, Fumitsugu
AU - Kawaminami, Katsuhiko
AU - Choudhury, Sohel R.
AU - Kiyohara, Yutaka
AU - Iida, Minoru
AU - Hashimoto, Tsutomu
AU - Terao, Atsushi
AU - Sawai, Koryo
AU - Shibata, Shigeo
PY - 2005
Y1 - 2005
N2 - Background: Proteinuria has been considered to be a prognostic marker for persons with diabetes mellitus, but only a limited number of studies about the relationship between proteinuria and mortality among general population has been available. Methods: The subjects were 10,897 individuals who participated in the National Cardiovascular Survey conducted in 1980 and who were aged 30 years or older living in 300 districts that had been randomly selected throughout Japan. The vital records were confirmed in 1999 and 7,203 subjects (3,180 males and 4,023 females) without a history of hypertension, stroke, heart disease, renal disease, or diabetes mellitus at the start of the study were investigated. Results: There were 126,825 person-years of follow-up. During the observed period of time, 371 died of cardiovascular causes, including 171 stroke deaths and 74 coronary deaths. The risk of proteinuria for cardiovascular mortality was greater than unity for those with a normal serum creatinine level, after adjusting for age and other cardiovascular disease risk factors. Conclusions: When contrasted with other cardiovascular disease risk factors, urinary protein is an independent risk factor for cardiovascular death among the Japanese population.
AB - Background: Proteinuria has been considered to be a prognostic marker for persons with diabetes mellitus, but only a limited number of studies about the relationship between proteinuria and mortality among general population has been available. Methods: The subjects were 10,897 individuals who participated in the National Cardiovascular Survey conducted in 1980 and who were aged 30 years or older living in 300 districts that had been randomly selected throughout Japan. The vital records were confirmed in 1999 and 7,203 subjects (3,180 males and 4,023 females) without a history of hypertension, stroke, heart disease, renal disease, or diabetes mellitus at the start of the study were investigated. Results: There were 126,825 person-years of follow-up. During the observed period of time, 371 died of cardiovascular causes, including 171 stroke deaths and 74 coronary deaths. The risk of proteinuria for cardiovascular mortality was greater than unity for those with a normal serum creatinine level, after adjusting for age and other cardiovascular disease risk factors. Conclusions: When contrasted with other cardiovascular disease risk factors, urinary protein is an independent risk factor for cardiovascular death among the Japanese population.
KW - Cardiovascular diseases
KW - Cohort studies
KW - Japan
KW - Mortality
KW - Proteinuria
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U2 - 10.2188/jea.15.146
DO - 10.2188/jea.15.146
M3 - Article
C2 - 16141633
AN - SCOPUS:25444457293
SN - 0917-5040
VL - 15
SP - 146
EP - 153
JO - Journal of epidemiology
JF - Journal of epidemiology
IS - 4
ER -
