Proteinuria is a prognostic marker for cardiovascular mortality: NIPPON DATA 80, 1980-1999

Shinichi Tanihara, Takehito Hayakawa, Izumi Oki, Yosikazu Nakamura, Kiyomi Sakata, Akira Okayama, Yasuyuki Fujita, Hirotsugu Ueshima, Osamu Iimura, Teruo Omae, Kazuo Ueda, Hiroshi Yanagawa, Kazunori Kodama, Fumiyoshi Kasagi, Tomonori Okamura, Yoshikuni Kita, Shigeyuki Saito, Kiyomi Sakata, Shinichi Tanihara, Hiroshi HoribeMasumi Minowa, Toshihiro Takeuchi, Mitsuru Hasebe, Fumitsugu Kusano, Katsuhiko Kawaminami, Sohel R. Choudhury, Yutaka Kiyohara, Minoru Iida, Tsutomu Hashimoto, Atsushi Terao, Koryo Sawai, Shigeo Shibata

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Background: Proteinuria has been considered to be a prognostic marker for persons with diabetes mellitus, but only a limited number of studies about the relationship between proteinuria and mortality among general population has been available. Methods: The subjects were 10,897 individuals who participated in the National Cardiovascular Survey conducted in 1980 and who were aged 30 years or older living in 300 districts that had been randomly selected throughout Japan. The vital records were confirmed in 1999 and 7,203 subjects (3,180 males and 4,023 females) without a history of hypertension, stroke, heart disease, renal disease, or diabetes mellitus at the start of the study were investigated. Results: There were 126,825 person-years of follow-up. During the observed period of time, 371 died of cardiovascular causes, including 171 stroke deaths and 74 coronary deaths. The risk of proteinuria for cardiovascular mortality was greater than unity for those with a normal serum creatinine level, after adjusting for age and other cardiovascular disease risk factors. Conclusions: When contrasted with other cardiovascular disease risk factors, urinary protein is an independent risk factor for cardiovascular death among the Japanese population.

Original languageEnglish
Pages (from-to)146-153
Number of pages8
JournalJournal of epidemiology
Issue number4
Publication statusPublished - 2005
Externally publishedYes


  • Cardiovascular diseases
  • Cohort studies
  • Japan
  • Mortality
  • Proteinuria

ASJC Scopus subject areas

  • Epidemiology


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