TY - JOUR
T1 - Psychosocial factors at work and inflammatory markers
T2 - Protocol for a systematic review and meta-analysis
AU - Eguchi, Hisashi
AU - Watanabe, Kazuhiro
AU - Kawakami, Norito
AU - Ando, Emiko
AU - Arima, Hideaki
AU - Asai, Yumi
AU - Inoue, Akiomi
AU - Inoue, Reiko
AU - Iwanaga, Mai
AU - Imamura, Kotaro
AU - Kobayashi, Yuka
AU - Nishida, Norimitsu
AU - Otsuka, Yasumasa
AU - Sakuraya, Asuka
AU - Tsuno, Kanami
AU - Shimazu, Akihito
AU - Tsutsumi, Akizumi
N1 - Funding Information:
Funding This work is supported by the Work-related Diseases Clinical Research Grant 2016 (160701-01) and 2018 (180701-01) from the Ministry of Health, Labour and Welfare, Japan.
Publisher Copyright:
© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Introduction Chronic inflammation may be a mediator for the development of cardiovascular disease (CVD), metabolic diseases and psychotic and neurodegenerative disorders. Meta-analytic associations between work-related psychosocial factors and inflammatory markers have shown that work-related psychosocial factors could affect the flexibility and balance of the immune system. However, few systematic reviews or meta-analyses have investigated the association between work-related psychosocial factors and inflammatory markers. Based on prospective studies, the present investigation will conduct a comprehensive systematic review and meta-analysis of the association between work-related psychosocial factors and inflammatory markers. Methods and analysis The systematic review and meta-analysis will include published studies identified from electronic databases (PubMed, EMBASE, PsycINFO, PsycARTICLES, Web of Science and Japan Medical Abstracts Society) according to recommendations of the Meta-analysis of Observational Studies in Epidemiology guideline. Inclusion criteria are studies that: Examined associations between work-related psychosocial factors and increased inflammatory markers; used longitudinal or prospective cohort designs; were conducted among workers; provided sufficient data for calculating ORs or relative risk with 95% CIs; were published as original articles in English or Japanese; and were published up to the end of 2017. Study selection, data extraction, quality assessment and statistical syntheses will be conducted by 14 investigators. Any inconsistencies or disagreements will be resolved through discussion. The quality of studies will be evaluated using the Risk of Bias Assessment Tool for Non-randomized Studies. Ethics and dissemination The investigation study will be based on published studies, so ethics approval is not required. The results of this study will be submitted for publication in a scientific peer-reviewed journal. The findings may be useful for assessing risk factors for increased inflammatory markers in the workplace and determining future approaches for preventing CVD, metabolic diseases and psychotic and neurodegenerative disorders. PROSPERO registration number CRD42018081553.
AB - Introduction Chronic inflammation may be a mediator for the development of cardiovascular disease (CVD), metabolic diseases and psychotic and neurodegenerative disorders. Meta-analytic associations between work-related psychosocial factors and inflammatory markers have shown that work-related psychosocial factors could affect the flexibility and balance of the immune system. However, few systematic reviews or meta-analyses have investigated the association between work-related psychosocial factors and inflammatory markers. Based on prospective studies, the present investigation will conduct a comprehensive systematic review and meta-analysis of the association between work-related psychosocial factors and inflammatory markers. Methods and analysis The systematic review and meta-analysis will include published studies identified from electronic databases (PubMed, EMBASE, PsycINFO, PsycARTICLES, Web of Science and Japan Medical Abstracts Society) according to recommendations of the Meta-analysis of Observational Studies in Epidemiology guideline. Inclusion criteria are studies that: Examined associations between work-related psychosocial factors and increased inflammatory markers; used longitudinal or prospective cohort designs; were conducted among workers; provided sufficient data for calculating ORs or relative risk with 95% CIs; were published as original articles in English or Japanese; and were published up to the end of 2017. Study selection, data extraction, quality assessment and statistical syntheses will be conducted by 14 investigators. Any inconsistencies or disagreements will be resolved through discussion. The quality of studies will be evaluated using the Risk of Bias Assessment Tool for Non-randomized Studies. Ethics and dissemination The investigation study will be based on published studies, so ethics approval is not required. The results of this study will be submitted for publication in a scientific peer-reviewed journal. The findings may be useful for assessing risk factors for increased inflammatory markers in the workplace and determining future approaches for preventing CVD, metabolic diseases and psychotic and neurodegenerative disorders. PROSPERO registration number CRD42018081553.
KW - cardiology
KW - inflammation
KW - mental health
KW - occupational health
KW - psychosocial factors at work
KW - workplace
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U2 - 10.1136/bmjopen-2018-022612
DO - 10.1136/bmjopen-2018-022612
M3 - Review article
C2 - 30158233
AN - SCOPUS:85052726643
SN - 2044-6055
VL - 8
JO - BMJ open
JF - BMJ open
IS - 8
M1 - e022612
ER -
