Pulmonary alveolar proteinosis associated with myelodysplastic syndrome

T. Terashima, H. Nakamura, S. Meguro, H. Fujimori, M. Mori, K. Yamaguchi, M. Kanazawa, R. Kato, K. Kobayashi

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6 Citations (Scopus)


A 57-year-old man with myelodysplastic syndrome developed dyspnea on exertion in September 1993. Chest X-ray film showed diffuse infiltrative shadows in the middle and lower lung fields on both sides. The infiltrates were prominent in the perihilar regions but less so in the periphery, consistent with a 'bat wing pattern.' Milky fluid was obtained by bronchoalveolar lavage. The specimens obtained from transbrochial lung biopsy were compatible with the pathological findings of pulmonary alveolar proteinosis with amorphous periodic acid-Sciff-positive materials in the alveolar spaces. Impaired function of alveolar macrophages was demonstrated from their abnormally low phagocytosis of FITC-labeled latex beads. Whole lung lavage under general anesthesia was done twice, but the patient died because of progression of respiratory failure.

Original languageEnglish
Pages (from-to)645-651
Number of pages7
JournalJapanese Journal of Thoracic Diseases
Issue number6
Publication statusPublished - 1995


  • Alveolar macrophage
  • Myelodysplastic syndrome
  • Phagocytic activity
  • Pulmonary proteinosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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