Pulmonary immunohistochemistry and serum levels of a surfactant-associated protein A in fatal drowning

Bao Li Zhu, Kaori Ishida, Li Quan, Dong Ri Li, Mari Taniguchi, Masaki Q. Fujita, Hitoshi Maeda, Tsutomu Tsuji

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47 Citations (Scopus)


To evaluate the immunohistochemical distribution and serum levels of a pulmonary surfactant-associated protein A (SP-A) in fatal drowning with regard to the pulmonary alveolar injury, 53 autopsy cases were investigated. SP-A was membranously or linearly demonstrated in varying intensities on the intra-alveolar interior surface and on the interface of the intra-alveolar effusion. A high score of intra-alveolar aggregates of SP-A was significantly more frequently observed in freshwater than saltwater drowning. The left/right ratios of cardiac blood SP-A level were significantly high both in fresh- and saltwater drowning, showing no relationship to aggregated SP-A scores. Immunohistochemical score and serum level of SP-A were independent of the lung weight or pleural effusion. These observations suggest a partial difference of pulmonary pathophysiology depending on the immersion medium in fatal drowning.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalLegal Medicine
Issue number1
Publication statusPublished - 2002
Externally publishedYes


  • Drowning
  • Forensic pathophysiology
  • Immunohistochemistry
  • Pulmonary surfactant-associated protein A
  • Serum level

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Issues, ethics and legal aspects


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