Pulmonary neuroendocrine tumors with nuclear inclusion

Saori Kobayashi, Koji Tsuta, Shigeki Sekine, Akihiko Yoshida, Naoshi Sasaki, Yasuo Shibuki, Hiroyuki Sakurai, Shun ichi Watanabe, Hisao Asamura, Hitoshi Tsuda

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Nuclear inclusion or pseudoinclusion is a peculiar cytological feature, and its recognition in appropriate clinicopathological settings can aid in the diagnosis of several disease entities. To the best of our knowledge, only 1 case of pulmonary neuroendocrine tumor (NET) with nuclear pseudoinclusion has been reported. A review of 227 patients who had undergone surgical resection for pulmonary NETs revealed 2 tumors with different mechanisms of nuclear inclusion. To explore the cause of nuclear inclusion, NET with nuclear inclusion was characterized immunohistochemically and ultrastructurally. Nuclear inclusions were observed in 2 of the 227 (0.9%) patients with pulmonary NETs. The first patient was a 46-year-old woman with small cell carcinoma. Tumor cells with nuclear inclusions were distributed focally. Ultrastructural analysis showed that these inclusions were pseudoinclusions. The second patient was a 62-year-old man with large-cell neuroendocrine carcinoma. Nuclear inclusions were observed in the focal area of the tumor. Immunohistochemical analysis revealed that the intra-nuclear materials consisted of biotin and aberrant cytoplasmic and nuclear accumulation of β-catenin. Mutational analysis revealed a CTNNB1 gene mutation.

Original languageEnglish
Pages (from-to)574-577
Number of pages4
JournalPathology Research and Practice
Issue number9
Publication statusPublished - 2013 Sept
Externally publishedYes


  • Nuclear inclusion
  • Pulmonary neuroendocrine tumor
  • β-Catenin mutation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology


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