Pulsed amperometry for anti-fouling of boron-doped diamond in electroanalysis of β-agonists: Application to flow injection for pharmaceutical analysis

Chanpen Karuwan; Thitirat Mantim; Patcharin Chaisuwan; Prapin Wilairat; Kate Grudpan; Piyada Jittangprasert; Yasuaki Einaga; Orawon Chailapakul; Leena Suntornsuk; Oraphan Anurukvorakun; Duangjai Nacapricha

doi:10.3390/s6121837

Pulsed amperometry for anti-fouling of boron-doped diamond in electroanalysis of β-agonists: Application to flow injection for pharmaceutical analysis

Chanpen Karuwan, Thitirat Mantim, Patcharin Chaisuwan, Prapin Wilairat, Kate Grudpan, Piyada Jittangprasert, Yasuaki Einaga, Orawon Chailapakul, Leena Suntornsuk, Oraphan Anurukvorakun, Duangjai Nacapricha

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

This work presents the construction and application of boron-doped diamond (BDD) thin film electrode as sensor for the determination of three β-agonists, viz. salbutamol, terbutaline and clenbuterol. Although well-known as a chemically inert material, BDD film however shows fouling in detection of these compounds using fixed-potential mode amperometry. A suitable waveform for pulsed amperometric detection (PAD) was developed and used to determine the agonist compounds. It was seen that the developed PAD significantly refreshed the BDD surface for long-term detection in flow injection analysis. Linear working ranges were 0.5-100 μM, 1.0-100 μM and 0.5-50 μM for salbutamol, terbutaline and clenbuterol, respectively. The developed PAD-BDD system was applied to successfully determine salbutamol and terbutaline in commercial pharmaceutical products. The methods were validated with a capillary electrophoresis method.

Original language	English
Pages (from-to)	1837-1850
Number of pages	14
Journal	Sensors
Volume	6
Issue number	12
DOIs	https://doi.org/10.3390/s6121837
Publication status	Published - 2006 Dec

Keywords

Boron-doped diamond
Flow injection
Pulsed amperometry
β-agonists

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Atomic and Molecular Physics, and Optics
Instrumentation
Electrical and Electronic Engineering

Access to Document

10.3390/s6121837

Cite this

Karuwan, C., Mantim, T., Chaisuwan, P., Wilairat, P., Grudpan, K., Jittangprasert, P., Einaga, Y., Chailapakul, O., Suntornsuk, L., Anurukvorakun, O., & Nacapricha, D. (2006). Pulsed amperometry for anti-fouling of boron-doped diamond in electroanalysis of β-agonists: Application to flow injection for pharmaceutical analysis. Sensors, 6(12), 1837-1850. https://doi.org/10.3390/s6121837

Karuwan, C, Mantim, T, Chaisuwan, P, Wilairat, P, Grudpan, K, Jittangprasert, P, Einaga, Y, Chailapakul, O, Suntornsuk, L, Anurukvorakun, O & Nacapricha, D 2006, 'Pulsed amperometry for anti-fouling of boron-doped diamond in electroanalysis of β-agonists: Application to flow injection for pharmaceutical analysis', Sensors, vol. 6, no. 12, pp. 1837-1850. https://doi.org/10.3390/s6121837

@article{30ddacf3dbe344e1baa41961057124c3,

title = "Pulsed amperometry for anti-fouling of boron-doped diamond in electroanalysis of β-agonists: Application to flow injection for pharmaceutical analysis",

abstract = "This work presents the construction and application of boron-doped diamond (BDD) thin film electrode as sensor for the determination of three β-agonists, viz. salbutamol, terbutaline and clenbuterol. Although well-known as a chemically inert material, BDD film however shows fouling in detection of these compounds using fixed-potential mode amperometry. A suitable waveform for pulsed amperometric detection (PAD) was developed and used to determine the agonist compounds. It was seen that the developed PAD significantly refreshed the BDD surface for long-term detection in flow injection analysis. Linear working ranges were 0.5-100 μM, 1.0-100 μM and 0.5-50 μM for salbutamol, terbutaline and clenbuterol, respectively. The developed PAD-BDD system was applied to successfully determine salbutamol and terbutaline in commercial pharmaceutical products. The methods were validated with a capillary electrophoresis method.",

keywords = "Boron-doped diamond, Flow injection, Pulsed amperometry, β-agonists",

author = "Chanpen Karuwan and Thitirat Mantim and Patcharin Chaisuwan and Prapin Wilairat and Kate Grudpan and Piyada Jittangprasert and Yasuaki Einaga and Orawon Chailapakul and Leena Suntornsuk and Oraphan Anurukvorakun and Duangjai Nacapricha",

year = "2006",

month = dec,

doi = "10.3390/s6121837",

language = "English",

volume = "6",

pages = "1837--1850",

journal = "Sensors",

issn = "1424-3210",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "12",

}

TY - JOUR

T1 - Pulsed amperometry for anti-fouling of boron-doped diamond in electroanalysis of β-agonists

T2 - Application to flow injection for pharmaceutical analysis

AU - Karuwan, Chanpen

AU - Mantim, Thitirat

AU - Chaisuwan, Patcharin

AU - Wilairat, Prapin

AU - Grudpan, Kate

AU - Jittangprasert, Piyada

AU - Einaga, Yasuaki

AU - Chailapakul, Orawon

AU - Suntornsuk, Leena

AU - Anurukvorakun, Oraphan

AU - Nacapricha, Duangjai

PY - 2006/12

Y1 - 2006/12

N2 - This work presents the construction and application of boron-doped diamond (BDD) thin film electrode as sensor for the determination of three β-agonists, viz. salbutamol, terbutaline and clenbuterol. Although well-known as a chemically inert material, BDD film however shows fouling in detection of these compounds using fixed-potential mode amperometry. A suitable waveform for pulsed amperometric detection (PAD) was developed and used to determine the agonist compounds. It was seen that the developed PAD significantly refreshed the BDD surface for long-term detection in flow injection analysis. Linear working ranges were 0.5-100 μM, 1.0-100 μM and 0.5-50 μM for salbutamol, terbutaline and clenbuterol, respectively. The developed PAD-BDD system was applied to successfully determine salbutamol and terbutaline in commercial pharmaceutical products. The methods were validated with a capillary electrophoresis method.

AB - This work presents the construction and application of boron-doped diamond (BDD) thin film electrode as sensor for the determination of three β-agonists, viz. salbutamol, terbutaline and clenbuterol. Although well-known as a chemically inert material, BDD film however shows fouling in detection of these compounds using fixed-potential mode amperometry. A suitable waveform for pulsed amperometric detection (PAD) was developed and used to determine the agonist compounds. It was seen that the developed PAD significantly refreshed the BDD surface for long-term detection in flow injection analysis. Linear working ranges were 0.5-100 μM, 1.0-100 μM and 0.5-50 μM for salbutamol, terbutaline and clenbuterol, respectively. The developed PAD-BDD system was applied to successfully determine salbutamol and terbutaline in commercial pharmaceutical products. The methods were validated with a capillary electrophoresis method.

KW - Boron-doped diamond

KW - Flow injection

KW - Pulsed amperometry

KW - β-agonists

UR - http://www.scopus.com/inward/record.url?scp=33947367459&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33947367459&partnerID=8YFLogxK

U2 - 10.3390/s6121837

DO - 10.3390/s6121837

M3 - Article

AN - SCOPUS:33947367459

SN - 1424-3210

VL - 6

SP - 1837

EP - 1850

JO - Sensors

JF - Sensors

IS - 12

ER -

Pulsed amperometry for anti-fouling of boron-doped diamond in electroanalysis of β-agonists: Application to flow injection for pharmaceutical analysis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this