TY - JOUR
T1 - Pyripyropenes, novel inhibitors of acyl-coa
T2 - Cholesterol acyltransferase produced by aspergillus fumigatus. II. Structure elucidation of pyripyropenes A, B, C and D
AU - Kim, Young Kook
AU - Tomoda, Hiroshi
AU - Nishida, Hiroyuki
AU - Sunazuka, Toshiaki
AU - Obata, Rika
AU - Omura, Satoshi
PY - 1994/1/1
Y1 - 1994/1/1
N2 - The structures of pyripyropenes A, B, C and D, novel acyl-CoA : cholesterol acyltransferase (ACAT) inhibitors, were determined mainly by spectroscopic studies including various NMR measurements. Pyripyropenes have a common structure which consists of pyridine, α-pyrone and sesquiterpene moieties. One of the three O-acetyl residues in the sesquiterpene moiety of pyripyropene A is replaced with an O-propionyl residue in pyripyropenes B, C and D.
AB - The structures of pyripyropenes A, B, C and D, novel acyl-CoA : cholesterol acyltransferase (ACAT) inhibitors, were determined mainly by spectroscopic studies including various NMR measurements. Pyripyropenes have a common structure which consists of pyridine, α-pyrone and sesquiterpene moieties. One of the three O-acetyl residues in the sesquiterpene moiety of pyripyropene A is replaced with an O-propionyl residue in pyripyropenes B, C and D.
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U2 - 10.7164/antibiotics.47.154
DO - 10.7164/antibiotics.47.154
M3 - Article
C2 - 8150710
AN - SCOPUS:0028280316
SN - 0021-8820
VL - 47
SP - 154
EP - 162
JO - The Journal of Antibiotics
JF - The Journal of Antibiotics
IS - 2
ER -