Quantitative and Molecular Similarity Analyses of the Metabolites of Cold- A nd Hot-Natured Chinese Herbs

Jing Guo, Jiaxiao Wang, Keiko Iino, Masaru Tomita, Tomoyoshi Soga

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Background. Based on the theory of traditional Chinese medicine, Chinese herbs possess four different medicinal properties: Hot, warm, cold, and cool. These serve as a reference guide for these herbal medicines. However, the molecular mechanisms supporting their relevance remain unclear. Methods. We performed metabolomics based on capillary electrophoresis-time-of-flight mass spectrometry (CE-TOF/MS) and multivariate data analysis for the structural identification of compounds of cold- A nd hot-natured Chinese herbs. Results. To this end, 30 selected herbs were analyzed and a total of 416 metabolites were identified via CE-TOF/MS, of which 193 compounds were detected in most herbs. The observed profiles offered the potential to understand the mechanism of association between the compounds and nature of the Chinese herbs. Comparison of the similarity in terms of chemical and molecular structures and content revealed that hot-natured herbs contained more nucleotides. In contrast, principal component analysis revealed the presence of more amino acid compounds in cold-natured herbs. Conclusion. Comparing the structural similarities between the samples using the Tanimoto coefficient revealed that a general non-specific structure was observed between cold- A nd hot-natured herbs; however, the distribution of the molecular groups seemed to contribute more toward the energy properties.

Original languageEnglish
Article number6646507
JournalEvidence-based Complementary and Alternative Medicine
Publication statusPublished - 2021

ASJC Scopus subject areas

  • Complementary and alternative medicine


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