Quantitative and Sensitive Detection of GNAS Mutations Causing McCune-Albright Syndrome with Next Generation Sequencing

Medicine & Life Sciences

• Polyostotic Fibrous Dysplasia 100%
• Peptide Nucleic Acids 64%
• High-Throughput Nucleotide Sequencing 63%
• Mutation 36%
• Mutation Rate 11%
• Polymerase Chain Reaction 6%
• DNA 6%
• Limit of Detection 5%
• Exons 4%

Agriculture & Biology

• mutation 45%
• nucleic acids 37%
• peptides 27%
• methodology 13%
• sampling 8%
• blood 8%
• somatic mutation 6%
• mutants 5%
• DNA 5%
• detection limit 4%
• exons 4%
• loci 3%

Chemical Compounds

• Mutation 55%
• Peptide Nucleic Acid 29%
• Dilution 7%
• Sequencing Method 7%
• Error 3%