Rab family small GTPases-mediated regulation of intracellular logistics in neural development

Mima Shikanai; Michisuke Yuzaki; Takeshi Kawauchi

doi:10.14670/HH-11-956

Rab family small GTPases-mediated regulation of intracellular logistics in neural development

Mima Shikanai, Michisuke Yuzaki, Takeshi Kawauchi

Department of Physiology

Research output: Contribution to journal › Review article › peer-review

13 Citations (Scopus)

Abstract

Rab family small GTPases play essential roles in various cellular events via the regulation of intracellular logistics comprising a large number of membrane traffic pathways. Emerging evidence reveals the physiological roles of Rab proteins in several tissues, including developing brains. Many Rab proteins, such as Rab5, Rab6, Rab7, Rab8, Rab10, Rab11, Rab17 and Rab18, are shown to regulate neurite outgrowth in PC12 cells and/or axon and dendrite formation in primary cultured neurons. Recent studies have also revealed in vivo roles of several Rab family small GTPases in brain development and its related neurological disorders. In this review, we introduce the physiological function of Rab family proteins in neural development with particular focus on neurite outgrowth and neuronal migration.

Original language	English
Pages (from-to)	765-771
Number of pages	7
Journal	Histology and Histopathology
Volume	33
Issue number	8
DOIs	https://doi.org/10.14670/HH-11-956
Publication status	Published - 2018 Aug

Keywords

Brain development
CdK5
Endocytosis
JNK
Membrane traffic
Neurite outgrowth
Neuronal migration
Rab10
Rab11
Rab17
Rab18
Rab5
Rab6
Rab7
Rab8

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology

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10.14670/HH-11-956

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title = "Rab family small GTPases-mediated regulation of intracellular logistics in neural development",

abstract = "Rab family small GTPases play essential roles in various cellular events via the regulation of intracellular logistics comprising a large number of membrane traffic pathways. Emerging evidence reveals the physiological roles of Rab proteins in several tissues, including developing brains. Many Rab proteins, such as Rab5, Rab6, Rab7, Rab8, Rab10, Rab11, Rab17 and Rab18, are shown to regulate neurite outgrowth in PC12 cells and/or axon and dendrite formation in primary cultured neurons. Recent studies have also revealed in vivo roles of several Rab family small GTPases in brain development and its related neurological disorders. In this review, we introduce the physiological function of Rab family proteins in neural development with particular focus on neurite outgrowth and neuronal migration.",

keywords = "Brain development, CdK5, Endocytosis, JNK, Membrane traffic, Neurite outgrowth, Neuronal migration, Rab10, Rab11, Rab17, Rab18, Rab5, Rab6, Rab7, Rab8",

author = "Mima Shikanai and Michisuke Yuzaki and Takeshi Kawauchi",

note = "Funding Information: Acknowledgements. The authors thank Dr. Ruth T. Yu for English proofreading of the manuscript. The authors{\textquoteright} research group is funded by JSPS KAKENHI Grant Numbers JP26290015 (to T.K.) and Grant-in Scientific Research on Innovation Areas “Dynamic regulation of Brain Function by Scrap & Build System” (JP17H05757 to T.K., JP16H06461 to M.Y.) from Ministry of Education, Culture, Sports, Science, and Technology of Japan (MEXT), AMED under Grant number JP17GM5010002 (to T.K.), and Takeda Science Foundation (to T.K.). Publisher Copyright: {\textcopyright} 2018, Histology and Histopathology. All rights reserved.",

year = "2018",

month = aug,

doi = "10.14670/HH-11-956",

language = "English",

volume = "33",

pages = "765--771",

journal = "Histology and Histopathology",

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AU - Yuzaki, Michisuke

AU - Kawauchi, Takeshi

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KW - Membrane traffic

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KW - Neuronal migration

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KW - Rab17

KW - Rab18

KW - Rab5

KW - Rab6

KW - Rab7

KW - Rab8

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JO - Histology and Histopathology

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ER -

Rab family small GTPases-mediated regulation of intracellular logistics in neural development

Abstract

Keywords

ASJC Scopus subject areas

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