## Abstract

Interaction between two homologous (i.e., identical or nearly identical) DNA sequences leads to their homologous recombination in the cell. We present the following stochastic model to explain the dependence of the frequency of homologous recombination on the length of the homologous region. The branch point connecting the two DNAs in a reaction intermediate follows the random-walk process along the homology (N base-pairs). If the branch point reaches either of the homology ends, it bounds back to the homologous region at a probability of γ (reflection coefficient) and is destroyed at a probability of 1-γ. When γ is small, the frequency of homologous recombination is found to be proportional to N3 for smaller N and a linear function of N for larger N. The exponent of the nonlinear dependence for smaller N decreases from three as γ increases. When γ=1, only the linear dependence is left. These theoretical results can explain many experimental data in various systems. (c) 1995 The American Physical Society

Original language | English |
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Pages (from-to) | 6607-6622 |

Number of pages | 16 |

Journal | Physical Review E |

Volume | 52 |

Issue number | 6 |

DOIs | |

Publication status | Published - 1995 |

Externally published | Yes |

## ASJC Scopus subject areas

- Statistical and Nonlinear Physics
- Statistics and Probability
- Condensed Matter Physics