Rare case of early mucosal gastric cancer presenting with metastasis to the bulbar conjunctiva

Jo Tokuyama, Tetsuro Kubota, Yoshihide Otani, Tomohisa Egawa, Norihito Wada, Yoshinori Sugino, Yukihiro Mashima, Yu Nakamura, Makio Mukai, Hiromasa Ishii, Masaki Kitajima

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Early gastric cancer has an excellent outcome following surgical treatment. In particular, mucosal gastric cancer (m-cancer) very rarely results in metastatic dissemination and may be successfully treated by local surgical resection. We report a 64-year-old Japanese woman who presented with a recurrent cystic lesion on the left bulbar conjunctiva, with a biopsy specimen revealing metastatic signet-ring cell carcinoma. Gastrointestinal investigations revealed an early gastric cancer in the lesser curvature of the stomach. Biopsy specimen of the gastric lesion indicated poorly differentiated adenocarcinoma, which was identical to findings in the lesion in the bulbar conjunctiva. She underwent a distal gastrectomy and made an uneventful recovery. Histopathological analysis indicated a gastric signet-ring cell carcinoma that was limited to the mucosal layer, without evidence of lymphatic spread. Although the exact mechanism of metastatic dissemination to the bulbar conjunctiva is unclear, this case is very unusual, because ocular metastases almost invariably occur in the context of documented and established malignant disease. This is, to our knowledge, the first reported case of a patient with gastric mucosal cancer who presented with a conjunctival metastatic deposit and who subsequently received curative surgical treatment for both conditions.

Original languageEnglish
Pages (from-to)102-106
Number of pages5
JournalGastric Cancer
Issue number2
Publication statusPublished - 2002
Externally publishedYes


  • Distant metastasis
  • Mucosal gastric cancer

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology
  • Cancer Research


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