Recent advances in the synthesis of morphine and related alkaloids

Noritaka Chida

Research output: Chapter in Book/Report/Conference proceedingChapter

35 Citations (Scopus)


Morphine, an alkaloid isolated from the opium poppy, has been widely used as an analgesic, and has been a fascinating synthetic target of organic chemists. After the first total synthesis reported in 1952, a number of synthetic studies toward morphine have been reported, and findings obtained in such studies have greatly contributed to the progress of synthetic organic chemistry as well as medicinal chemistry. This review provides an overview of recent studies toward the total synthesis of morphine and related alkaloids. Work reported in the literature since 2004 will be reviewed.

Original languageEnglish
Title of host publicationChemistry of Opioids
EditorsHiroshi Nagase
Number of pages28
Publication statusPublished - 2011

Publication series

NameTopics in Current Chemistry
ISSN (Print)0340-1022


  • Chiral synthesis
  • Codeine
  • Morphine
  • Total synthesis

ASJC Scopus subject areas

  • General Chemistry


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