Receptor tyrosine kinases involved in hematopoietic progenitor cells

Toshio Suda, Atsushi Iwama, Motohiro Hashiyama, Seiji Sakano, Mitsuharu Ohno

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


To analyze the molecular mechanisms of the proliferation and differentiation of hematopoietic cells, we have cloned PTKs from sorted stem cells. We discuss the expression and function of receptor tyrosine kinases, STK/RON, TIE, TEK and HTK which have been cloned from these cells. STK and its ligand, MSP contributed to the motility and phagocytosis of peritoneal macrophages and bone absorption of osteoclasts. Apoptosis was induced in an erythrorid cell line by the binding of MSP(MacrophageStimulating Protein). TIE, TEK and HTK were interestingly expressed in the subpopulations of stem cells and related to the myeloid differentiation. These study will indicate the heterogeneity of stem cells and their diverse differentiation.

Original languageEnglish
Pages (from-to)451-453
Number of pages3
Issue numberSUPPL. 3
Publication statusPublished - 1997 Jan 1

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research


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