Recurrence-free survival more than 10 years after liver resection for hepatocellular carcinoma

S. Eguchi, T. Kanematsu, S. Arii, M. Omata, M. Kudo, M. Sakamoto, K. Takayasu, M. Makuuchi, Y. Matsuyama, M. Monden

Research output: Contribution to journalArticlepeer-review

76 Citations (Scopus)


Background: High recurrence rates after liver resection with curative intent for hepatocellular carcinoma (HCC) remain a problem. The characterization of long-term survivors without recurrence after liver resection may help improve the therapeutic strategy for HCC. Methods: A nationwide Japanese database was used to analyse 20 811 patients with HCC who underwent liver resection with curative intent. Results: The 10-year recurrence-free survival rate after liver resection for HCC with curative intent was 22·4 per cent. Some 281 patients were recurrence-free after more than 10 years. The HCCs measured less than 5 cm in 83·2 per cent, a single lesion was present in 91·7 per cent, and a simple nodular macroscopic appearance was found in 73·3 per cent of these patients; histologically, most HCCs showed no vascular invasion or intrahepatic metastases. Multivariable analysis revealed tumour differentiation as the strongest predictor of death from recurrent HCC within 5 years. Conclusion: Long-term recurrence-free survival is possible after liver resection for HCC, particularly in patients with a single lesion measuring less than 5 cm with a simple nodular appearance and low tumour marker levels.

Original languageEnglish
Pages (from-to)552-557
Number of pages6
JournalBritish Journal of Surgery
Issue number4
Publication statusPublished - 2011 Apr

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Recurrence-free survival more than 10 years after liver resection for hepatocellular carcinoma'. Together they form a unique fingerprint.

Cite this