Recurrence of monoclonal gammopathy associated with donor-derived myelodysplastic syndrome after cord blood stem cell transplantation

Rie Yamazaki; Hideki Nakasone; Hidenori Wada; Kana Sakamoto; Masahiro Ashizawa; Miki Sato; Kiriko Terasako; Misato Kikuchi; Shun ichi Kimura; Shinya Okuda; Shinichi Kako; Yukie Tanaka; Aki Tanihara; Kumi Oshima; Junji Nishida; Yoshinobu Kanda

doi:10.1016/j.exphem.2011.09.002

Recurrence of monoclonal gammopathy associated with donor-derived myelodysplastic syndrome after cord blood stem cell transplantation

Rie Yamazaki, Hideki Nakasone, Hidenori Wada, Kana Sakamoto, Masahiro Ashizawa, Miki Sato, Kiriko Terasako, Misato Kikuchi, Shun ichi Kimura, Shinya Okuda, Shinichi Kako, Yukie Tanaka, Aki Tanihara, Kumi Oshima, Junji Nishida, Yoshinobu Kanda

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Myelodysplastic syndrome (MDS) is known to be associated with functional abnormalities of B cells, including hypergammaglobulinemia and monoclonal gammopathy (MG). However, the pathogenesis of these immunological disorders has not been clarified. We report a patient who developed donor-derived MDS followed by leukemic transformation after cord blood transplantation for MDS with MG. Interestingly, MG reappeared before development of donor-derived MDS. We analyzed the immunoglobulin allotype gene polymorphisms to determine whether the MG after cord blood transplantation was of recipient origin or donor origin. Results of genetic analysis and enzyme-linked immunosorbent assay of IgG1 allotype revealed that the MG after cord blood transplantation was of donor origin. Although the mechanism of donor-derived MG remains unclear, the persistent presence of recipient's antigen presenting cells might have induced the abnormal immunoglobulin production.

Original language	English
Pages (from-to)	1119-1123
Number of pages	5
Journal	Experimental Hematology
Volume	39
Issue number	12
DOIs	https://doi.org/10.1016/j.exphem.2011.09.002
Publication status	Published - 2011 Dec
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Hematology
Genetics
Cell Biology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.exphem.2011.09.002

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Yamazaki, R., Nakasone, H., Wada, H., Sakamoto, K., Ashizawa, M., Sato, M., Terasako, K., Kikuchi, M., Kimura, S. I., Okuda, S., Kako, S., Tanaka, Y., Tanihara, A., Oshima, K., Nishida, J., & Kanda, Y. (2011). Recurrence of monoclonal gammopathy associated with donor-derived myelodysplastic syndrome after cord blood stem cell transplantation. Experimental Hematology, 39(12), 1119-1123. https://doi.org/10.1016/j.exphem.2011.09.002

Yamazaki, R, Nakasone, H, Wada, H, Sakamoto, K, Ashizawa, M, Sato, M, Terasako, K, Kikuchi, M, Kimura, SI, Okuda, S, Kako, S, Tanaka, Y, Tanihara, A, Oshima, K, Nishida, J & Kanda, Y 2011, 'Recurrence of monoclonal gammopathy associated with donor-derived myelodysplastic syndrome after cord blood stem cell transplantation', Experimental Hematology, vol. 39, no. 12, pp. 1119-1123. https://doi.org/10.1016/j.exphem.2011.09.002

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abstract = "Myelodysplastic syndrome (MDS) is known to be associated with functional abnormalities of B cells, including hypergammaglobulinemia and monoclonal gammopathy (MG). However, the pathogenesis of these immunological disorders has not been clarified. We report a patient who developed donor-derived MDS followed by leukemic transformation after cord blood transplantation for MDS with MG. Interestingly, MG reappeared before development of donor-derived MDS. We analyzed the immunoglobulin allotype gene polymorphisms to determine whether the MG after cord blood transplantation was of recipient origin or donor origin. Results of genetic analysis and enzyme-linked immunosorbent assay of IgG1 allotype revealed that the MG after cord blood transplantation was of donor origin. Although the mechanism of donor-derived MG remains unclear, the persistent presence of recipient's antigen presenting cells might have induced the abnormal immunoglobulin production.",

author = "Rie Yamazaki and Hideki Nakasone and Hidenori Wada and Kana Sakamoto and Masahiro Ashizawa and Miki Sato and Kiriko Terasako and Misato Kikuchi and Kimura, {Shun ichi} and Shinya Okuda and Shinichi Kako and Yukie Tanaka and Aki Tanihara and Kumi Oshima and Junji Nishida and Yoshinobu Kanda",

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doi = "10.1016/j.exphem.2011.09.002",

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AU - Yamazaki, Rie

AU - Nakasone, Hideki

AU - Wada, Hidenori

AU - Sakamoto, Kana

AU - Ashizawa, Masahiro

AU - Sato, Miki

AU - Terasako, Kiriko

AU - Kikuchi, Misato

AU - Kimura, Shun ichi

AU - Okuda, Shinya

AU - Kako, Shinichi

AU - Tanaka, Yukie

AU - Tanihara, Aki

AU - Oshima, Kumi

AU - Nishida, Junji

AU - Kanda, Yoshinobu

PY - 2011/12

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AB - Myelodysplastic syndrome (MDS) is known to be associated with functional abnormalities of B cells, including hypergammaglobulinemia and monoclonal gammopathy (MG). However, the pathogenesis of these immunological disorders has not been clarified. We report a patient who developed donor-derived MDS followed by leukemic transformation after cord blood transplantation for MDS with MG. Interestingly, MG reappeared before development of donor-derived MDS. We analyzed the immunoglobulin allotype gene polymorphisms to determine whether the MG after cord blood transplantation was of recipient origin or donor origin. Results of genetic analysis and enzyme-linked immunosorbent assay of IgG1 allotype revealed that the MG after cord blood transplantation was of donor origin. Although the mechanism of donor-derived MG remains unclear, the persistent presence of recipient's antigen presenting cells might have induced the abnormal immunoglobulin production.

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Recurrence of monoclonal gammopathy associated with donor-derived myelodysplastic syndrome after cord blood stem cell transplantation

Abstract

ASJC Scopus subject areas

UN SDGs

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