Recurrent bacterial pneumonia due to immunoglobulin G2 subclass deficiency after allogeneic hematopoietic stem cell transplantation: Efficacy of immunoglobulin replacement

Rie Yamazaki; Taku Kikuchi; Jun Kato; Masatoshi Sakurai; Yuya Koda; Risa Hashida; Yusuke Yamane; Ryohei Abe; Naoki Hasegawa; Shinichiro Okamoto; Takehiko Mori

doi:10.1111/tid.12863

Recurrent bacterial pneumonia due to immunoglobulin G2 subclass deficiency after allogeneic hematopoietic stem cell transplantation: Efficacy of immunoglobulin replacement

Rie Yamazaki, Taku Kikuchi, Jun Kato, Masatoshi Sakurai, Yuya Koda, Risa Hashida, Yusuke Yamane, Ryohei Abe, Naoki Hasegawa, Shinichiro Okamoto, Takehiko Mori

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Immunoglobulin (Ig) G2 subclass deficiency is known to be associated with recurrent bacterial respiratory infections caused by capsulated bacteria. We encountered a case of recurrent pneumonia due to Streptococcus pneumoniae after allogeneic hematopoietic stem cell transplantation (HSCT). IgG2 subclass level was specifically low, and prophylactic Ig replacement successfully prevented subsequent infections. However, the cessation of Ig replacement resulted in subsequent pneumonia. These findings suggested that IgG2 deficiency could be a cause of recurrent pneumococcal infection after allogeneic HSCT.

Original language	English
Journal	Transplant Infectious Disease
DOIs	https://doi.org/10.1111/tid.12863
Publication status	Accepted/In press - 2018 Jan 1

Keywords

Allogeneic hematopoietic stem cell transplantation
Immunoglobulin G2 deficiency
Pneumonia
Streptococcus pneumoniae

ASJC Scopus subject areas

Transplantation
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/tid.12863

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Yamazaki, R., Kikuchi, T., Kato, J., Sakurai, M., Koda, Y., Hashida, R., Yamane, Y., Abe, R., Hasegawa, N., Okamoto, S., & Mori, T. (Accepted/In press). Recurrent bacterial pneumonia due to immunoglobulin G2 subclass deficiency after allogeneic hematopoietic stem cell transplantation: Efficacy of immunoglobulin replacement. Transplant Infectious Disease. https://doi.org/10.1111/tid.12863

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abstract = "Immunoglobulin (Ig) G2 subclass deficiency is known to be associated with recurrent bacterial respiratory infections caused by capsulated bacteria. We encountered a case of recurrent pneumonia due to Streptococcus pneumoniae after allogeneic hematopoietic stem cell transplantation (HSCT). IgG2 subclass level was specifically low, and prophylactic Ig replacement successfully prevented subsequent infections. However, the cessation of Ig replacement resulted in subsequent pneumonia. These findings suggested that IgG2 deficiency could be a cause of recurrent pneumococcal infection after allogeneic HSCT.",

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author = "Rie Yamazaki and Taku Kikuchi and Jun Kato and Masatoshi Sakurai and Yuya Koda and Risa Hashida and Yusuke Yamane and Ryohei Abe and Naoki Hasegawa and Shinichiro Okamoto and Takehiko Mori",

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doi = "10.1111/tid.12863",

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T1 - Recurrent bacterial pneumonia due to immunoglobulin G2 subclass deficiency after allogeneic hematopoietic stem cell transplantation

T2 - Efficacy of immunoglobulin replacement

AU - Yamazaki, Rie

AU - Kikuchi, Taku

AU - Kato, Jun

AU - Sakurai, Masatoshi

AU - Koda, Yuya

AU - Hashida, Risa

AU - Yamane, Yusuke

AU - Abe, Ryohei

AU - Hasegawa, Naoki

AU - Okamoto, Shinichiro

AU - Mori, Takehiko

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Immunoglobulin (Ig) G2 subclass deficiency is known to be associated with recurrent bacterial respiratory infections caused by capsulated bacteria. We encountered a case of recurrent pneumonia due to Streptococcus pneumoniae after allogeneic hematopoietic stem cell transplantation (HSCT). IgG2 subclass level was specifically low, and prophylactic Ig replacement successfully prevented subsequent infections. However, the cessation of Ig replacement resulted in subsequent pneumonia. These findings suggested that IgG2 deficiency could be a cause of recurrent pneumococcal infection after allogeneic HSCT.

AB - Immunoglobulin (Ig) G2 subclass deficiency is known to be associated with recurrent bacterial respiratory infections caused by capsulated bacteria. We encountered a case of recurrent pneumonia due to Streptococcus pneumoniae after allogeneic hematopoietic stem cell transplantation (HSCT). IgG2 subclass level was specifically low, and prophylactic Ig replacement successfully prevented subsequent infections. However, the cessation of Ig replacement resulted in subsequent pneumonia. These findings suggested that IgG2 deficiency could be a cause of recurrent pneumococcal infection after allogeneic HSCT.

KW - Allogeneic hematopoietic stem cell transplantation

KW - Immunoglobulin G2 deficiency

KW - Pneumonia

KW - Streptococcus pneumoniae

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Recurrent bacterial pneumonia due to immunoglobulin G2 subclass deficiency after allogeneic hematopoietic stem cell transplantation: Efficacy of immunoglobulin replacement

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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