Red Fluorescence Probe Targeted to Dipeptidylpeptidase-IV for Highly Sensitive Detection of Esophageal Cancer

Akira Ogasawara; Mako Kamiya; Kei Sakamoto; Yugo Kuriki; Kyohhei Fujita; Toru Komatsu; Tasuku Ueno; Kenjiro Hanaoka; Haruna Onoyama; Hiroyuki Abe; Yosuke Tsuji; Mitsuhiro Fujishiro; Kazuhiko Koike; Masashi Fukayama; Yasuyuki Seto; Yasuteru Urano

doi:10.1021/acs.bioconjchem.9b00198

Red Fluorescence Probe Targeted to Dipeptidylpeptidase-IV for Highly Sensitive Detection of Esophageal Cancer

Akira Ogasawara, Mako Kamiya, Kei Sakamoto, Yugo Kuriki, Kyohhei Fujita, Toru Komatsu, Tasuku Ueno, Kenjiro Hanaoka, Haruna Onoyama, Hiroyuki Abe, Yosuke Tsuji, Mitsuhiro Fujishiro, Kazuhiko Koike, Masashi Fukayama, Yasuyuki Seto, Yasuteru Urano

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

We have developed an activatable red fluorescence probe for dipeptidylpeptidase-IV (DPP-IV) by precisely controlling the photoinduced electron transfer (PeT) process of a red fluorescent scaffold, SiR600. The developed probe exhibited an extremely low background signal and showed significant fluorescence activation upon reaction with DPP-IV, enabling sensitive detection of esophageal cancer in clinical specimens from cancer patients.

Original language	English
Pages (from-to)	1055-1060
Number of pages	6
Journal	Bioconjugate Chemistry
Volume	30
Issue number	4
DOIs	https://doi.org/10.1021/acs.bioconjchem.9b00198
Publication status	Published - 2019 Apr 17
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomedical Engineering
Pharmacology
Pharmaceutical Science
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acs.bioconjchem.9b00198

Cite this

Ogasawara, A., Kamiya, M., Sakamoto, K., Kuriki, Y., Fujita, K., Komatsu, T., Ueno, T., Hanaoka, K., Onoyama, H., Abe, H., Tsuji, Y., Fujishiro, M., Koike, K., Fukayama, M., Seto, Y., & Urano, Y. (2019). Red Fluorescence Probe Targeted to Dipeptidylpeptidase-IV for Highly Sensitive Detection of Esophageal Cancer. Bioconjugate Chemistry, 30(4), 1055-1060. https://doi.org/10.1021/acs.bioconjchem.9b00198

Ogasawara, A, Kamiya, M, Sakamoto, K, Kuriki, Y, Fujita, K, Komatsu, T, Ueno, T, Hanaoka, K, Onoyama, H, Abe, H, Tsuji, Y, Fujishiro, M, Koike, K, Fukayama, M, Seto, Y & Urano, Y 2019, 'Red Fluorescence Probe Targeted to Dipeptidylpeptidase-IV for Highly Sensitive Detection of Esophageal Cancer', Bioconjugate Chemistry, vol. 30, no. 4, pp. 1055-1060. https://doi.org/10.1021/acs.bioconjchem.9b00198

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title = "Red Fluorescence Probe Targeted to Dipeptidylpeptidase-IV for Highly Sensitive Detection of Esophageal Cancer",

abstract = "We have developed an activatable red fluorescence probe for dipeptidylpeptidase-IV (DPP-IV) by precisely controlling the photoinduced electron transfer (PeT) process of a red fluorescent scaffold, SiR600. The developed probe exhibited an extremely low background signal and showed significant fluorescence activation upon reaction with DPP-IV, enabling sensitive detection of esophageal cancer in clinical specimens from cancer patients.",

author = "Akira Ogasawara and Mako Kamiya and Kei Sakamoto and Yugo Kuriki and Kyohhei Fujita and Toru Komatsu and Tasuku Ueno and Kenjiro Hanaoka and Haruna Onoyama and Hiroyuki Abe and Yosuke Tsuji and Mitsuhiro Fujishiro and Kazuhiko Koike and Masashi Fukayama and Yasuyuki Seto and Yasuteru Urano",

note = "Funding Information: This research was supported in part by JST/PRESTO grant JPMJPR14F8 (to M.K.), by MEXT/JSPS KAKENHI grants JP16H02606, JP26111012 (to Y.U.) and JP15H05951 “Resonance Bio” (to M.K.), 16H06574 (to T.U.), by JSPS Core-to-Core Program, A. Advanced Research Networks, by grants from Hoansha Foundation (to Y.U.), Astellas foundation for research on metabolic disorders (to M.K.), and Japan Foundation for Applied Enzymology (to M.K.). Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",

year = "2019",

month = apr,

day = "17",

doi = "10.1021/acs.bioconjchem.9b00198",

language = "English",

volume = "30",

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T1 - Red Fluorescence Probe Targeted to Dipeptidylpeptidase-IV for Highly Sensitive Detection of Esophageal Cancer

AU - Ogasawara, Akira

AU - Kamiya, Mako

AU - Sakamoto, Kei

AU - Kuriki, Yugo

AU - Fujita, Kyohhei

AU - Komatsu, Toru

AU - Ueno, Tasuku

AU - Hanaoka, Kenjiro

AU - Onoyama, Haruna

AU - Abe, Hiroyuki

AU - Tsuji, Yosuke

AU - Fujishiro, Mitsuhiro

AU - Koike, Kazuhiko

AU - Fukayama, Masashi

AU - Seto, Yasuyuki

AU - Urano, Yasuteru

N1 - Funding Information: This research was supported in part by JST/PRESTO grant JPMJPR14F8 (to M.K.), by MEXT/JSPS KAKENHI grants JP16H02606, JP26111012 (to Y.U.) and JP15H05951 “Resonance Bio” (to M.K.), 16H06574 (to T.U.), by JSPS Core-to-Core Program, A. Advanced Research Networks, by grants from Hoansha Foundation (to Y.U.), Astellas foundation for research on metabolic disorders (to M.K.), and Japan Foundation for Applied Enzymology (to M.K.). Publisher Copyright: © 2019 American Chemical Society.

PY - 2019/4/17

Y1 - 2019/4/17

N2 - We have developed an activatable red fluorescence probe for dipeptidylpeptidase-IV (DPP-IV) by precisely controlling the photoinduced electron transfer (PeT) process of a red fluorescent scaffold, SiR600. The developed probe exhibited an extremely low background signal and showed significant fluorescence activation upon reaction with DPP-IV, enabling sensitive detection of esophageal cancer in clinical specimens from cancer patients.

AB - We have developed an activatable red fluorescence probe for dipeptidylpeptidase-IV (DPP-IV) by precisely controlling the photoinduced electron transfer (PeT) process of a red fluorescent scaffold, SiR600. The developed probe exhibited an extremely low background signal and showed significant fluorescence activation upon reaction with DPP-IV, enabling sensitive detection of esophageal cancer in clinical specimens from cancer patients.

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Red Fluorescence Probe Targeted to Dipeptidylpeptidase-IV for Highly Sensitive Detection of Esophageal Cancer

Abstract

ASJC Scopus subject areas

UN SDGs

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