Red fluorescent probe for monitoring the dynamics of cytoplasmic calcium ions

Takahiro Egawa, Kazuhisa Hirabayashi, Yuichiro Koide, Chiaki Kobayashi, Naoya Takahashi, Tomoko Mineno, Takuya Terai, Tasuku Ueno, Toru Komatsu, Yuji Ikegaya, Norio Matsuki, Tetsuo Nagano, Kenjiro Hanaoka

Research output: Contribution to journalArticlepeer-review

71 Citations (Scopus)


We see red (and yellow and green): Probe 1 was developed for the visualization of cytoplasmic Ca2+, a pivotal second messenger in many biological responses. The new probe is suitable for multicolor imaging for the simultaneous detection of metal ions or proteins and is superior to the existing red fluorescent probe Rhod-2 for the monitoring of cytoplasmic Ca2+ oscillation in cultured cells (see fluorescence images of cells with 1 (top) and Rhod-2 (bottom)).

Original languageEnglish
Pages (from-to)3874-3877
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number14
Publication statusPublished - 2013 Apr 2
Externally publishedYes


  • bioimaging
  • calcium
  • cell signaling
  • fluorescence
  • imaging agents

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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